雄性挪威棕色大鼠血清和脑内雄激素水平的年龄相关变化。
Age-related changes in serum and brain levels of androgens in male Brown Norway rats.
作者信息
Rosario Emily R, Chang Lilly, Beckett Tina L, Carroll Jenna C, Paul Murphy M, Stanczyk Frank Z, Pike Christian J
机构信息
Neuroscience Graduate Program, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
出版信息
Neuroreport. 2009 Nov 25;20(17):1534-7. doi: 10.1097/WNR.0b013e328331f968.
Abstract
Age-related depletion of androgens in men results in functional impairments in androgen-responsive tissues, such as the brain, resulting in increased risk for Alzheimer's disease. To investigate the relationship between normal age-related hormone loss and Alzheimer's disease risk, we evaluated the brain and serum levels of androgens and estrogen in aging male rats. We observed that increasing age was associated with a significant reduction in brain levels of the potent androgen dihydrotestosterone and a trend toward decreased testosterone. Brain levels of soluble beta-amyloid were observed to increase with age. Collectively, these findings highlight differences in brain and circulating levels of androgens during aging, and identify an inverse correlation with beta-amyloid levels that may be relevant to Alzheimer's disease risk.
摘要
男性体内雄激素随年龄增长而减少，会导致雄激素反应性组织（如大脑）出现功能障碍，从而增加患阿尔茨海默病的风险。为了研究正常的年龄相关激素流失与阿尔茨海默病风险之间的关系，我们评估了衰老雄性大鼠大脑和血清中的雄激素和雌激素水平。我们观察到，随着年龄增长，强效雄激素双氢睾酮的大脑水平显著降低，睾酮水平也有下降趋势。可溶性β-淀粉样蛋白的大脑水平随年龄增长而升高。总体而言，这些发现突出了衰老过程中大脑和循环中雄激素水平的差异，并确定了与β-淀粉样蛋白水平呈负相关，这可能与阿尔茨海默病风险有关。
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