Rosario Emily R, Chang Lilly, Beckett Tina L, Carroll Jenna C, Paul Murphy M, Stanczyk Frank Z, Pike Christian J
Neuroscience Graduate Program, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Neuroreport. 2009 Nov 25;20(17):1534-7. doi: 10.1097/WNR.0b013e328331f968.
Age-related depletion of androgens in men results in functional impairments in androgen-responsive tissues, such as the brain, resulting in increased risk for Alzheimer's disease. To investigate the relationship between normal age-related hormone loss and Alzheimer's disease risk, we evaluated the brain and serum levels of androgens and estrogen in aging male rats. We observed that increasing age was associated with a significant reduction in brain levels of the potent androgen dihydrotestosterone and a trend toward decreased testosterone. Brain levels of soluble beta-amyloid were observed to increase with age. Collectively, these findings highlight differences in brain and circulating levels of androgens during aging, and identify an inverse correlation with beta-amyloid levels that may be relevant to Alzheimer's disease risk.
男性体内雄激素随年龄增长而减少，会导致雄激素反应性组织（如大脑）出现功能障碍，从而增加患阿尔茨海默病的风险。为了研究正常的年龄相关激素流失与阿尔茨海默病风险之间的关系，我们评估了衰老雄性大鼠大脑和血清中的雄激素和雌激素水平。我们观察到，随着年龄增长，强效雄激素双氢睾酮的大脑水平显著降低，睾酮水平也有下降趋势。可溶性β-淀粉样蛋白的大脑水平随年龄增长而升高。总体而言，这些发现突出了衰老过程中大脑和循环中雄激素水平的差异，并确定了与β-淀粉样蛋白水平呈负相关，这可能与阿尔茨海默病风险有关。
