Kerdemelidis Melissa, Lennon Diana, Arroll Bruce, Peat Briar
Community Paediatrics, School of Population Health, The University of Auckland, Auckland, New Zealand.
N Z Med J. 2009 Aug 21;122(1301):10-8.
Untreated group A streptococcal (GAS) sore throats can cause acute rheumatic fever (ARF), with permanent cardiac damage in 30%. An algorithm and guideline for appropriate screening and management of sore throats in the New Zealand setting was crafted to guide appropriate treatment in high risk rheumatic fever areas and reduce antibiotic use in low risk areas.
Three American sore throat guidelines were used as a framework, and searches were made of databases including Medline, Old Medline, Cochrane, DARE, Central, NHS EED, WHOLIS, (www.clinicalevidence.com), and (www.pubmed.gov). No European guidelines were available.
A guideline for GAS pharyngitis was created, including an algorithm which stratifies patients according to their risk of ARF. Revised Centor criteria to determine the likelihood of GAS pharyngitis were used. Patients at medium or high risk for GAS pharyngitis should have throat swabs taken if possible. Recommended treatment tables are given.
Patients presenting with sore throats need to have their risk of developing rheumatic fever assessed, and then the risk of GAS pharyngitis determined. Appropriate antibiotic therapy is instigated on the basis of proven or likely GAS pharyngitis. Ten days of oral penicillin V is the first-line treatment. Other household members are at high risk of infection. Unnecessary antibiotic use is a guiding principle in low risk patients.
未经治疗的A组链球菌(GAS)性咽喉痛可引发急性风湿热(ARF),其中30%会造成永久性心脏损伤。制定了一套适用于新西兰环境的咽喉痛适当筛查和管理算法及指南,以指导风湿热高风险地区的适当治疗,并减少低风险地区的抗生素使用。
以三项美国咽喉痛指南为框架,对包括医学在线数据库(Medline)、旧医学在线数据库(Old Medline)、考克兰图书馆(Cochrane)、循证医学数据库(DARE)、循证医学中心数据库(Central)、英国国家卫生服务经济评价数据库(NHS EED)、世界卫生组织图书馆信息系统(WHOLIS)(www.clinicalevidence.com)以及(www.pubmed.gov)在内的数据库进行检索。未找到欧洲指南。
制定了GAS咽炎指南,包括一项根据患者患ARF的风险对其进行分层的算法。采用了经修订的森托标准来确定GAS咽炎的可能性。GAS咽炎中风险或高风险的患者应尽可能进行咽喉拭子检查。给出了推荐治疗表。
出现咽喉痛的患者需要评估其患风湿热的风险,然后确定患GAS咽炎的风险。根据已证实或可能的GAS咽炎进行适当的抗生素治疗。口服青霉素V十天是一线治疗方法。其他家庭成员感染风险高。在低风险患者中,避免不必要地使用抗生素是一项指导原则。