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儿童扁桃体炎和咽喉痛

Tonsillitis and sore throat in children.

作者信息

Stelter Klaus

机构信息

Dep. of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Centre, University of Munich, Munich, Germany.

出版信息

GMS Curr Top Otorhinolaryngol Head Neck Surg. 2014 Dec 1;13:Doc07. doi: 10.3205/cto000110. eCollection 2014.

DOI:10.3205/cto000110
PMID:25587367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4273168/
Abstract

Surgery of the tonsils is still one of the most frequent procedures during childhood. Due to a series of fatal outcomes after hemorrhage in children in Austria in 2006, the standards and indications for tonsillectomy have slowly changed in Germany. However, no national guidelines exist and the frequency of tonsil surgery varies across the country. In some districts eight times more children were tonsillectomized than in others. A tonsillectomy in children under six years should only be done if the child suffers from recurrent acute bacterially tonsillitis. In all other cases (i.e. hyperplasia of the tonsils) the low risk partial tonsillectomy should be the first line therapy. Postoperative pain and the risk of hemorrhage are much lower in partial tonsillectomy (=tonsillotomy). No matter whether the tonsillotomy is done by laser, radiofrequency, shaver, coblation, bipolar scissor or Colorado needle, as long as the crypts are kept open and some tonsil tissue is left behind. Total extracapsular tonsillectomy is still indicated in severely affected children with recurrent infections of the tonsils, allergy to antibiotics, PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis) and peritonsillar abscess. With regard to the frequency and seriousness of the recurrent tonsillitis the indication for tonsillectomy in children is justified if 7 or more well-documented, clinically important, adequately treated episodes of throat infection occur in the preceding year, or 5 or more of such episodes occur in each of the 2 preceding years (according to the paradise criteria). Diagnosis of acute tonsillitis is clinical, but sometimes it is hard to distinguish viral from bacterial infections. Rapid antigen testing has a very low sensitivity in the diagnosis of bacterial tonsillitis and swabs are highly sensitive but take a long time. In all microbiological tests the treating physician has to keep in mind, that most of the bacterials, viruses and fungi belong to the healthy flora and do no harm. Ten percent of healthy children even bear strepptococcus pyogenes all the time in the tonsils with no clinical signs. In these children decolonization is not necessary. Therefore, microbiological screening tests in children without symptoms are senseless and do not justify an antibiotic treatment (which is sometimes postulated by the kindergartens). The acute tonsillitis should be treated with steroids (e.g. dexamethasone), NSAIDs (e.g. ibuprofene) and betalactam antibiotics (e.g. penicillin or cefuroxime). With respect to the symptom reduction and primary healing the short-term late-generation antibiotic therapy (azithromycin, clarithromycin or cephalosporine for three to five days) is comparable to the long-term penicilline therapy. There is no difference in the course of healing, recurrence or microbiological resistance between the short-term penicilline therapy and the standard ten days therapy. On the other hand, only the ten days antibiotic therapy has proven to be effective in the prevention of rheumatic fever and glomerulonephritic diseases. The incidence of rheumatic heart disease is currently 0.5 per 100,000 children of school age. The main morbidity after tonsillectomy is pain and the late haemorrhage. Posttonsillectomy bleeding can occur till the whole wound is completely healed, which is normally after three weeks. Life-threatening haemorrhages occur often after smaller bleedings, which can spontaneously cease. That is why every haemorrhage, even the smallest, has to be treated properly and in ward. Patients and parents have to be informed about the correct behaviour in case of haemorrhage with a written consent before the surgery. The handout should contain important addresses, phone numbers and contact persons. Almost all cases of fatal outcome after tonsillectomy were due to false management of haemorrhage. Haemorrhage in small children can be especially life-threatening because of the lower blood volume and the danger of aspiration with asphyxia. A massive haemorrhage is an extreme challenge for every paramedic or emergency doctor because of the difficult airway management. Intubation is only possible with appropriate inflexible suction tubes. All different surgical techniques have the risk of haemorrhage and even the best surgeon will experience a postoperative haemorrhage. The lowest risk of haemorrhage is after cold dissection with ligature or suturing. All "hot" techniques with laser, radiofrequency, coblation, mono- or bipolar forceps have a higher risk of late haemorrhage. Children with a hereditary coagulopathy have a higher risk of haemorrhage. It is possible, that these children were not identified before surgery. Therefore it is recommended by the Society of paediatrics, anaesthesia and ENT, that a standardised questionnaire should be answered by the parents before tonsillectomy and adenoidectomy. This 17-point-checklist questionnaire is more sensitive and easier to perform than a screening with blood tests (e.g. INR and PTT). Unfortunately, a lot of surgeons still screen the children preoperatively by coagulative blood tests, although these tests are inappropriate and incapable of detecting the von Willebrand disease, which is the most frequent coagulopathy in Europe. The preoperative information about the surgery should be done with the child and the parents in a calm and objective atmosphere with a written consent. A copy of the consent with the signature of the surgeon and both custodial parents has to be handed out to the parents.

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摘要

扁桃体手术仍是儿童期最常见的手术之一。2006年奥地利儿童术后出血出现一系列致命后果后,德国扁桃体切除术的标准和适应症逐渐发生了变化。然而,德国没有全国性指南,扁桃体手术的频率在全国范围内各不相同。在一些地区,接受扁桃体切除术的儿童数量比其他地区多八倍。六岁以下儿童只有在患有复发性急性细菌性扁桃体炎时才应进行扁桃体切除术。在所有其他情况下(如扁桃体增生),低风险的部分扁桃体切除术应作为一线治疗方法。部分扁桃体切除术(即扁桃体切开术)术后疼痛和出血风险要低得多。无论扁桃体切开术是通过激光、射频、刨削器、低温等离子、双极剪刀还是科罗拉多针进行,只要隐窝保持开放且留有一些扁桃体组织即可。对于扁桃体反复严重感染、对抗生素过敏、PFAPA综合征(周期性发热、口疮性口炎、咽炎和颈淋巴结炎)以及扁桃体周围脓肿的重症患儿,仍需进行完全囊外扁桃体切除术。就复发性扁桃体炎的发作频率和严重程度而言,如果前一年有7次或更多记录良好、具有临床重要性且得到充分治疗的咽喉感染发作,或者在前两年中每年有5次或更多此类发作(根据天堂标准),那么对儿童进行扁桃体切除术是合理的。急性扁桃体炎的诊断基于临床,但有时很难区分病毒感染和细菌感染。快速抗原检测在细菌性扁桃体炎诊断中的敏感性非常低,咽拭子检测敏感性高但耗时较长。在所有微生物检测中,治疗医生必须牢记,大多数细菌、病毒和真菌属于健康菌群,不会造成危害。10%的健康儿童扁桃体中一直携带化脓性链球菌,但无临床症状。对于这些儿童,无需进行去定植治疗。因此,对无症状儿童进行微生物筛查毫无意义,也无法证明抗生素治疗的合理性(幼儿园有时会要求进行此类治疗)。急性扁桃体炎应使用类固醇(如地塞米松)、非甾体抗炎药(如布洛芬)和β-内酰胺抗生素(如青霉素或头孢呋辛)进行治疗。就症状缓解和初步愈合而言,短期的新一代抗生素治疗(阿奇霉素、克拉霉素或头孢菌素,疗程为三至五天)与长期青霉素治疗相当。短期青霉素治疗与标准的十天治疗在愈合过程、复发或微生物耐药性方面没有差异。另一方面,只有十天的抗生素治疗已被证明对预防风湿热和肾小球肾炎有效。目前,学龄儿童风湿性心脏病的发病率为十万分之0.5。扁桃体切除术后的主要并发症是疼痛和晚期出血。扁桃体切除术后出血可能会持续到整个伤口完全愈合,通常在三周后。危及生命的大出血往往发生在较小的出血之后,这些小出血可能会自行停止。这就是为什么每一次出血,即使是最小的出血,都必须在病房得到妥善治疗。手术前,必须告知患者及其家长出血时的正确应对措施,并取得书面同意。手册应包含重要地址、电话号码和联系人。扁桃体切除术后几乎所有的致命后果都是由于出血处理不当所致。由于幼儿血容量较低且有吸入窒息的危险,幼儿出血尤其危及生命。对于每一位护理人员或急诊医生来说,大出血都是一项巨大的挑战,因为气道管理困难。只有使用合适的硬质吸引管才能进行插管。所有不同的手术技术都有出血风险,即使是最优秀的外科医生也会遇到术后出血的情况。出血风险最低的是冷剥离加结扎或缝合术后。所有使用激光、射频、低温等离子、单极或双极钳的“热”技术都有较高的晚期出血风险。患有遗传性凝血障碍的儿童出血风险更高。有可能这些儿童在手术前未被识别出来。因此,儿科、麻醉和耳鼻喉学会建议,在扁桃体切除术和腺样体切除术之前,家长应填写一份标准化问卷。这份17项检查清单问卷比血液检测(如国际标准化比值和活化部分凝血活酶时间)筛查更敏感、更易于操作。不幸的是,许多外科医生仍然在术前通过凝血功能血液检测对儿童进行筛查,尽管这些检测并不合适,也无法检测出欧洲最常见的凝血障碍——血管性血友病。术前应在平静、客观的氛围中与患儿及其家长进行手术相关信息的沟通,并取得书面同意。必须向家长发放一份由外科医生以及两位监护人签字的同意书副本。

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Paediatr Anaesth. 2013 Aug;23(8):690-6. doi: 10.1111/pan.12170. Epub 2013 May 13.
6
Posttonsillectomy hemorrhage in children with von Willebrand disease or hemophilia.儿童扁桃体切除术后 von Willebrand 病或血友病出血。
JAMA Otolaryngol Head Neck Surg. 2013 Mar;139(3):245-9. doi: 10.1001/jamaoto.2013.1821.
7
Different antibiotic treatments for group A streptococcal pharyngitis.A组链球菌性咽炎的不同抗生素治疗方法。
Cochrane Database Syst Rev. 2013 Apr 30(4):CD004406. doi: 10.1002/14651858.CD004406.pub3.
8
[Faults and failure of tonsil surgery and other standard procedures in otorhinolaryngology].[耳鼻喉科扁桃体手术及其他标准手术的失误与失败]
Laryngorhinootologie. 2013 Apr;92 Suppl 1:S33-72. doi: 10.1055/s-0032-1333253. Epub 2013 Apr 26.
9
A review of the pathogenesis of adult peritonsillar abscess: time for a re-evaluation.成人扁桃体周脓肿发病机制的综述:重新评估的时机。
J Antimicrob Chemother. 2013 Sep;68(9):1941-50. doi: 10.1093/jac/dkt128. Epub 2013 Apr 23.
10
The need and challenges for development of an Epstein-Barr virus vaccine.开发 Epstein-Barr 病毒疫苗的必要性和挑战。
Vaccine. 2013 Apr 18;31 Suppl 2(0 2):B194-6. doi: 10.1016/j.vaccine.2012.09.041.