Arilla E, Fragoso J, Barrio R, Colás B, Donnay S, Roca B, Hernández M
Departamento de Bioquímica y Biologia Molecular, Facultad de Medicina, Universidad de Alcalá de Henares, España.
Horm Res. 1990;34(2):71-4. doi: 10.1159/000181798.
To date, the effects of long-term growth hormone (GH)-releasing hormone [GHRH(1-29)-NH2] treatment on the plasma concentrations of somatostatin-like immunoreactivity (SLI) remain undefined. In the present study, the effect of GHRH(1-29)-NH2 therapy on plasma SLI levels has been studied in 11 non-GH-deficient children. The pattern of administration was 5 micrograms/kg body weight, given subcutaneously once every day. There was no significant change in plasma SLI levels after bolus injection of GHRH(1-29)-NH2 before and during GHRH(1-29)-NH2 therapy. However, plasma SLI rose in basal plasma and nocturnal sleep after 3 months of GHRH(1-29)-NH2 therapy and remained the same during 6 months of treatment with GHRH(1-29)-NH2. The reason for this finding is uncertain, but an increase in SLI release from the enteroinsular axis is a possible explanation. The association of our findings with the role of the circulating SLI on nutrient homeostasis and the effects of GNRH on growth velocity is discussed.
迄今为止，长期生长激素释放激素[GHRH(1 - 29)-NH₂]治疗对血浆中生长抑素样免疫活性物质（SLI）浓度的影响仍不明确。在本研究中，对11名非生长激素缺乏的儿童进行了GHRH(1 - 29)-NH₂治疗对血浆SLI水平影响的研究。给药方式为5微克/千克体重，每天皮下注射一次。在GHRH(1 - 29)-NH₂治疗前及治疗期间，推注GHRH(1 - 29)-NH₂后血浆SLI水平无显著变化。然而，GHRH(1 - 29)-NH₂治疗3个月后，基础血浆和夜间睡眠时的血浆SLI升高，且在GHRH(1 - 29)-NH₂治疗6个月期间保持不变。这一发现的原因尚不确定，但肠胰岛轴释放的SLI增加是一种可能的解释。文中讨论了我们的研究结果与循环SLI在营养稳态中的作用以及促性腺激素释放激素对生长速度的影响之间的关联。
