Rosskamp R, Becker M, Tegeler A, Klumpp J
Department of Pediatrics, University of Bonn, FRG.
Horm Res. 1987;27(3):121-5. doi: 10.1159/000180799.
In response to insulin-induced hypoglycemia (0.1 U insulin/kg body weight, i.v.) plasma levels of growth hormone-releasing hormone (GHRH), somatostatin (SLI), and growth hormone (GH) were measured by radioimmunoassay in 10 children with short stature. Insulin injection resulted in a significant increase in plasma GHRH values at 15 min (10.0 +/- 0.5 vs. 17.1 +/- 3.1 pg/ml; p less than 0.05) preceding the increase in plasma GH levels (1.5 +/- 0.4 vs. 13.6 +/- 1.2 ng/ml; p less than 0.001). SLI concentrations peaked between 15 and 60 min after insulin injection (20.9 +/- 1.2 vs. 47.1 +/- 6.2 pg/ml; p less than 0.01). No correlation was present between plasma GHRH or SLI levels and plasma GH concentrations. A significant negative correlation could be established between maximum increments of plasma GHRH and SLI levels (r = -0.843; p less than 0.01) in response to insulin injection. This finding suggests a possible relationship between these two hormones at peripheral level.
通过放射免疫分析法，对10名身材矮小儿童在静脉注射胰岛素诱发低血糖（0.1 U胰岛素/千克体重）后，测量其血浆生长激素释放激素（GHRH）、生长抑素（SLI）和生长激素（GH）水平。胰岛素注射后15分钟，血浆GHRH值显著升高（10.0±0.5对17.1±3.1 pg/ml；p<0.05），随后血浆GH水平升高（1.5±0.4对13.6±1.2 ng/ml；p<0.001）。SLI浓度在胰岛素注射后15至60分钟达到峰值（20.9±1.2对47.1±6.2 pg/ml；p<0.01）。血浆GHRH或SLI水平与血浆GH浓度之间无相关性。胰岛素注射后，血浆GHRH和SLI水平的最大增量之间可建立显著的负相关（r = -0.843；p<0.01）。这一发现提示这两种激素在外周水平可能存在某种关系。
