卵巢甾体类激素可阻断异丙肾上腺素诱导的雌性大鼠松果体褪黑素分泌增加。

Ovarian steroids block the isoproterenol-induced elevation of pineal melatonin production in the female rat.

作者信息

Moujir F, Bordón R, Santana C, Abreu P, Hernandez G, Alonso R

机构信息

Department of Physiology, University of La Laguna School of Medicine, Tenerife, Spain.

出版信息

Neurosci Lett. 1990 Oct 30;119(1):12-4. doi: 10.1016/0304-3940(90)90743-s.

DOI:10.1016/0304-3940(90)90743-s

PMID:1982958

Abstract

Changes in pineal indole metabolism during the estrous cycle, as well as in response to estrogen administration, were studied in female rats. Tyrosine hydroxylase (TH) activity, norepinephrine (NE) and indoleamine levels were determined by high-performance liquid chromatography (HPLC). Pineal melatonin was measured by radioimmunoassay (RIA). Both 5-hydroxytryptamine (5-HT) and melatonin levels, but not TH activity or NE content, were reduced during proestrus. Ovarian hormones blocked the isoproterenol-induced elevation of pineal melatonin, and reduced 5-HT levels in ovariectomized rats. These results suggest that an estrogen-induced inhibition of the pineal response to adrenergic stimulation, could be responsible for the reduction in pineal melatonin production occurring during the proestrus stage of the rat estrous cycle.

摘要

研究了雌性大鼠发情周期期间以及给予雌激素后松果体吲哚代谢的变化。通过高效液相色谱法（HPLC）测定酪氨酸羟化酶（TH）活性、去甲肾上腺素（NE）和吲哚胺水平。通过放射免疫分析法（RIA）测定松果体褪黑素。在发情前期，5-羟色胺（5-HT）和褪黑素水平均降低，但TH活性或NE含量未降低。卵巢激素可阻断异丙肾上腺素诱导的松果体褪黑素升高，并降低去卵巢大鼠的5-HT水平。这些结果表明，雌激素诱导的对松果体对肾上腺素能刺激反应的抑制，可能是大鼠发情周期发情前期松果体褪黑素产生减少的原因。