全氢-1,4-噻氮杂䓬和全氢-1,2,5-二噻氮杂䓬衍生物的一些药理学性质。
Some pharmacological properties of perhydro-1,4-thiazepine and perhydro-1,2,5-dithiazepine derivatives.
作者信息
Strzelczyk M, Matyjewska H, Strózyński H
机构信息
Department of Biochemistry, Pharmacology and Biology, Military Medical Academy, Lódź, Poland.
出版信息
Pol J Pharmacol Pharm. 1990 Jul-Aug;42(4):377-85.
PMID:1982963
Abstract
Some newly synthesized perhydro-1,2,5-dithiazepine derivatives have antihistaminic, anticholinergic and spasmolytic properties. One perhydro-1,4-thiazepine derivative, compound 3, produces also a weak local anesthetic effect. The activity of the investigated compounds is lower than that of reference compounds; diphenhydramine, antazoline and papaverine.
摘要
一些新合成的全氢-1,2,5-二硫氮杂卓衍生物具有抗组胺、抗胆碱能和解痉特性。一种全氢-1,4-硫氮杂卓衍生物，化合物3，还具有微弱的局部麻醉作用。所研究化合物的活性低于对照化合物；苯海拉明、安他唑啉和罂粟碱。
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