Ozer Ozden, Eskazan Ahmet Emre, Ar M Cem, Beköz Hüseyin, Tabak Fehmi, Ongen Gül, Ferhanoglu Burhan
J Med Case Rep. 2009 Jun 23;3:7306. doi: 10.4076/1752-1947-3-7306.
Sarcoidosis is a granulomatous disease that mostly involves the lungs. Its association with malignancies has been well documented. Several mechanisms have been proposed that may underlie this concurrence including triggering tumour antigens and defective cellular immunity.
We briefly review the literature on malignancy associated sarcoidosis and report two female lymphoma patients of 49 and 56 years of age who, during their course of disease, developed sarcoidosis that was misinterpreted as a lymphoma relapse on positron emission tomography-computed tomography.
We hypothesise that T cell dysfunction and exposure to tumour associated antigens might be the underlying mechanisms of development of sarcoidosis in patients with lymphoma. Positron emission tomography-positive lesions do not always indicate malignancy and therefore a tissue biopsy is always mandatory to confirm the diagnosis.
结节病是一种主要累及肺部的肉芽肿性疾病。其与恶性肿瘤的关联已有充分记录。已提出多种可能导致这种并发情况的机制，包括触发肿瘤抗原和细胞免疫缺陷。
我们简要回顾了关于恶性肿瘤相关结节病的文献，并报告了两名分别为49岁和56岁的女性淋巴瘤患者，她们在疾病过程中出现了结节病，在正电子发射断层扫描 - 计算机断层扫描中被误诊为淋巴瘤复发。
我们推测T细胞功能障碍和接触肿瘤相关抗原可能是淋巴瘤患者发生结节病的潜在机制。正电子发射断层扫描阳性病变并不总是提示恶性肿瘤，因此组织活检对于确诊始终是必需的。
