Garland A J, Mowat G N, Fletton B
Dev Biol Stand. 1976;35:323-32.
The relative merits of various in vitro assay systems for the measurement of the quality and quantity of foot-and-mouth disease virus vaccine antigen will be discussed. The assay systems include : viral infectivity, complement fixing activity, particle counts, radial diffusion titre and single radial haemolysis titre. The predictive value of the tests for the immunogenicity of the final vaccine product will be evaluated against the results of 50% Protective Dose titres determined in guinea pigs and cattle by antibody assay and by challenge.
将讨论用于测量口蹄疫病毒疫苗抗原质量和数量的各种体外检测系统的相对优点。这些检测系统包括：病毒感染性、补体结合活性、颗粒计数、径向扩散滴度和单向辐射溶血滴度。将根据通过抗体检测和攻毒在豚鼠和牛中测定的50%保护剂量滴度的结果，评估这些检测对最终疫苗产品免疫原性的预测价值。
