The Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry & Chemical Engineering, Guangxi Normal University, Guilin 541004, China.
Bioinorg Chem Appl. 2009;2009:347872. doi: 10.1155/2009/347872. Epub 2009 Oct 8.
Complexes of copper (II) with hesperetin, naringenin, and apigenin of general composition [CuL(2)(H(2)O)(2)] nH(2)O (1-3) have been synthesized and characterized by elemental analysis, UV-Vis, FT-IR, ESI-MS, and TG-DTG thermal analysis. The free ligands and the metal complexes have been tested in vitro against human cancer cell lines hepatocellular carcinoma (HepG-2), gastric carcinomas (SGC-7901), and cervical carcinoma (HeLa). Complexes 1 and 3 were found to exhibit growth inhibition of SGC-7901 and HepG2 cell lines with respect to the free ligands; the inhibitory rate of complex 1 is 43.2% and 43.8%, while complex 3 is 46% and 36%, respectively. The interactions of complex 1 and its ligand Hsp with calf thymus DNA were investigated by UV-Vis, fluorescence, and CD spectra. Both complex 1 and Hsp were found to bind DNA in intercalation modes, and the binding affinity of complex 1 was stronger than that of free ligand.
已合成并通过元素分析、UV-Vis、FT-IR、ESI-MS 和 TG-DTG 热分析对铜（II）与橘皮素、柚皮苷和芹菜素的配合物 [CuL(2)(H(2)O)(2)] nH(2)O（1-3）进行了表征。已在体外对游离配体和金属配合物进行了针对肝癌细胞系（HepG-2）、胃癌细胞系（SGC-7901）和宫颈癌细胞系（HeLa）的测试。与游离配体相比，配合物 1 和 3 被发现对 SGC-7901 和 HepG2 细胞系具有生长抑制作用；配合物 1 的抑制率分别为 43.2%和 43.8%，而配合物 3 的抑制率分别为 46%和 36%。通过 UV-Vis、荧光和 CD 光谱研究了配合物 1 及其配体 Hsp 与小牛胸腺 DNA 的相互作用。发现配合物 1 和 Hsp 均以嵌入模式与 DNA 结合，且配合物 1 的结合亲和力强于游离配体。
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