手性联苯酰胺衍生物：一种高效的有机催化剂，用于手性选择性合成α-羟基膦酸酯。
Chiral biphenylamide derivative: an efficient organocatalyst for the enantioselective synthesis of alpha-hydroxy phosphonates.
机构信息
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China.
出版信息
Org Biomol Chem. 2009 Nov 7;7(21):4355-7. doi: 10.1039/b917554g. Epub 2009 Sep 17.
DOI:10.1039/b917554g
PMID:19830282
Abstract
The aldol reactions of alpha-keto phosphonates and aldehydes were facilitated by an axially chiral biphenylprolinamide under mild conditions, affording the synthetically and pharmaceutically useful products in high yields and excellent enantioselectivities.
摘要
在温和条件下，手性联苯脯氨酰胺促进了α-酮膦酸酯和醛之间的羟醛缩合反应，以高产率和优异的对映选择性得到了具有合成和药物用途的有用产物。
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