Ecole Nationale Supérieure de Chimie de Paris, Laboratoire Charles Friedel (UMR 7223, CNRS), 11 rue Pierre et Marie Curie, 75231 Paris cedex 05, France.
Org Lett. 2013 Aug 16;15(16):4274-6. doi: 10.1021/ol402059w. Epub 2013 Aug 1.
A new approach for the preparation of enantioenriched α-amino phosphonates and derivatives is described. Indeed, the rhodium-catalyzed asymmetric 1,4-addition of potassium organotrifluoroborates to dehydroaminophosphonates afforded α-amino phosphonates in good yields and high enantioselectivities (up to 96%) using Difluorphos as a chiral ligand.
描述了一种制备对映体富集的α-氨基膦酸酯及衍生物的新方法。事实上，使用 Difluorphos 作为手性配体，通过铑催化的钾有机三氟硼酸盐对脱水氨基膦酸盐的不对称 1,4-加成反应，以良好的收率和高对映选择性（高达 96%）得到α-氨基膦酸酯。
