一种高效制备肽醇的方法。
An efficient method for the preparation of peptide alcohols.
机构信息
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA.
出版信息
Org Biomol Chem. 2009 Nov 7;7(21):4444-7. doi: 10.1039/b905730g. Epub 2009 Aug 26.
DOI:10.1039/b905730g
PMID:19830293
Abstract
N-protected LL-dipeptide alcohols 3a-p, diastereomeric mixture (3d + 3d') and tripeptide alcohols 6a-c were synthesized by treatment of various amino alcohols with N-protected(alpha-aminoacyl)benzotriazoles 1a-c, 1f-m, (1a + 1a') and N-protected(alpha-dipeptidoyl)benzotriazoles 5a, 5b respectively in good yields with complete retention of chirality.
摘要
N-保护的 LL-二肽醇 3a-p、非对映异构体混合物（3d + 3d'）和三肽醇 6a-c 通过用 N-保护的（α-氨基酰基）苯并三唑 1a-c、1f-m、（1a + 1a'）和 N-保护的（α-二肽酰基）苯并三唑 5a、5b 处理各种氨基醇来合成，收率良好，且具有完全保留的手性。
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