Efficient microwave assisted access to chiral O-(alpha-protected-aminoacyl)steroids.
作者信息
Katritzky Alan R, Angrish Parul
机构信息
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, 32611-7200, USA.
出版信息
Steroids. 2006 Aug;71(8):660-9. doi: 10.1016/j.steroids.2006.04.003. Epub 2006 Jun 15.
Abstract
Chiral O-(alpha-protected-aminoacyl)steroids 4a-f, 6a-b, 8 and 4a+4d and O-(alpha-protected-dipeptidoyl)steroids 12a,b are conveniently prepared under microwave irradiation in isolated yields of 65-96%, with complete chirality retention. The reaction utilized readily available N-(Z-alpha-aminoacyl)benzotriazoles 2a-f and Z-dipeptidoylbenzotriazole 11, with naturally occurring steroidal alcohols 3,5,7,9.
摘要
Zotero 插件