Pribytkov Iu N, Shilkina N P, Poltyrev A S
Revmatologiia (Mosk). 1990 Jul-Sep(3):7-11.
Using the radioimmunological method the authors studied the level of prostaglandins (PG) E and F2 alpha in 76 patients with rheumatic diseases (RD) including 34 with various forms of systemic vasculitis (SV), 30 with systemic lupus erythematosus (SLE) and 12 with systemic sclerodermia (SSD). The condition of the microcirculatory bed was assessed by the method of bulbar angioscopy. A relationship between PG and first of all the pressor series, and the nature of vascular lesions in patients with RD was established. Hyperproduction of PGE was revealed in patients with lupus nephritis and SV in whom diseases ran their course with involvement of the kidneys and the nervous system. The level of PGF2 alpha correlated with the markedness of vascular disorders in patients with ischemic and vasospastic syndromes as well as with skin forms of vasculitis in SLE.
作者采用放射免疫法研究了76例风湿性疾病（RD）患者体内前列腺素（PG）E和F2α的水平，其中包括34例各种形式的系统性血管炎（SV）患者、30例系统性红斑狼疮（SLE）患者和12例系统性硬皮病（SSD）患者。采用球结膜血管镜检查法评估微循环床的状况。确定了PG与RD患者首先是升压系列以及血管病变性质之间的关系。在狼疮性肾炎和SV患者中发现PGE过度产生，这些疾病在累及肾脏和神经系统的情况下发展。PGF2α水平与缺血性和血管痉挛综合征患者的血管紊乱程度以及SLE患者的皮肤血管炎形式相关。
