Terré J, Stellmann C, Brun A, Favre H, Fontaine J
Dev Biol Stand. 1976;35:357-67.
Two methods of evaluating the activity of the foot-and-mouth disease vaccine are compared, leading to the evaluation of the number of protective doses 50% or potency. These methods differ in sensitivity, precision and equivalence potency-percentage of protection. For the same vaccine the value of the PD50 is always larger than that of Pb. We chose the Pb method using a diluent containing no adjuvant. Standards based on the evaluation of average potency have not been taken into consideration; only those standards based on the evaluation of minimum potency ensure respect of OIE's recommendation. This recommendation: 70% minimum potency with 0.95 probability is not an easier alternative, since the average protection observed corresponds in fact to at least 90% taking into account the biological variability of bovines.
比较了两种评估口蹄疫疫苗活性的方法，从而评估50%保护剂量或效力的数量。这些方法在敏感性、精密度以及效力-保护百分比的等效性方面存在差异。对于同一疫苗，PD50的值总是大于Pb的值。我们选择了使用不含佐剂稀释剂的Pb方法。未考虑基于平均效力评估的标准；只有基于最低效力评估的标准才能确保符合世界动物卫生组织（OIE）的建议。该建议：最低效力为70%且概率为0.95并非更容易的选择，因为考虑到牛的生物学变异性，实际观察到的平均保护率事实上至少为90%。
