Koizumi F, Ohneda M, Ohneda A
Department of Clinical and Laboratory Medicine, Tohoku University School of Medicine, Sendai.
Tohoku J Exp Med. 1990 Dec;162(4):355-62. doi: 10.1620/tjem.162.355.
The effect of cholinergic and adrenergic influences on pancreatic polypeptide (PP) release was studied in dogs. Administration of acetylcholine resulted in an elevation of plasma PP, whereas epinephrine induced no increase. Insulin-induced hypoglycemia increased plasma PP in a conscious state but not in anesthetized dogs. The infusion of phentolamine or propranolol did not affect the response of plasma PP to insulin-induced hypoglycemia, whereas atropine markedly inhibited the increase in plasma PP. Likewise, atropine reduced the rise of plasma PP during the intravenous administration of 2-deoxy-D-glucose (2-DG). We conclude from the present experiments that cholinergic mechanisms are of major importance in the response of PP to insulin- and 2-DG-induced glucoprivation, while the major role of the adrenergic mechanism was not proved.
在犬类中研究了胆碱能和肾上腺素能影响对胰多肽（PP）释放的作用。给予乙酰胆碱会导致血浆PP升高，而肾上腺素则不会使其升高。胰岛素诱导的低血糖在清醒状态下会增加血浆PP，但在麻醉犬中则不会。输注酚妥拉明或普萘洛尔不影响血浆PP对胰岛素诱导的低血糖的反应，而阿托品则显著抑制血浆PP的升高。同样，阿托品可降低静脉注射2-脱氧-D-葡萄糖（2-DG）期间血浆PP的升高。我们从目前的实验得出结论，胆碱能机制在PP对胰岛素和2-DG诱导的糖缺乏反应中起主要作用，而肾上腺素能机制的主要作用尚未得到证实。
