Gavrila D, Antúnez C, Tormo M J, Carles R, García Santos J M, Parrilla G, Fortuna L, Jiménez J, Salmerón D, Navarro C
Epidemiology Department, Murcia Health Council, Murcia, Spain.
Acta Neurol Scand. 2009 Nov;120(5):300-7. doi: 10.1111/j.1600-0404.2009.01283.x.
To estimate the prevalence of amnestic mild cognitive impairment (aMCI), cognitive impairment, no dementia (CIND) and dementia in a general elderly population and to examine the associated socio-demographic factors.
The Ariadna study is a population-based cross-sectional study of cognitive function involving 1074 individuals aged 65-96 years from the Murcia Region of southeastern Spain. Prevalence, adjusted odds ratio (OR) and 95% confidence intervals (CI) were calculated.
The overall prevalence was 8.7% (95% CI 7.1-10.5) for aMCI, 14.5% (95% CI 12.4-16.8) for CIND and 5.5% (95% CI 4.3-7.1) for dementia. Dementia was associated with age (OR 1.13 95% CI 1.09-1.18 for a 1-year increase in age). Illiterate subjects were more likely to present aMCI (OR 2.59; 95% CI 1.09-6.14) and dementia (OR 4.09; 95% CI 1.28-13.08) than subjects with secondary or higher education. Rural area residents (OR 2.13, 95% CI 1.07-4.24) and women (OR 1.53, 95% CI 1.06-2.22) were more likely to have CIND.
The prevalence of dementia was low, despite a high prevalence of aMCI and CIND. Dementia was strongly associated with age and education. CIND was associated with living in a rural area and with female sex, while aMCI was associated with illiteracy.
评估普通老年人群中遗忘型轻度认知障碍（aMCI）、认知障碍但无痴呆（CIND）及痴呆的患病率，并研究相关社会人口学因素。
阿丽亚娜研究是一项基于人群的认知功能横断面研究，涉及西班牙东南部穆尔西亚地区1074名65 - 96岁的个体。计算患病率、调整后的优势比（OR）及95%置信区间（CI）。
aMCI的总体患病率为8.7%（95%CI 7.1 - 10.5），CIND为14.5%（95%CI 12.4 - 16.8），痴呆为5.5%（95%CI 4.3 - 7.1）。痴呆与年龄相关（年龄每增加1岁，OR为1.13，95%CI 1.09 - 1.18）。与接受过中等或高等教育的受试者相比，文盲受试者更易出现aMCI（OR 2.59；95%CI 1.09 - 6.14）和痴呆（OR 4.09；95%CI 1.28 - 13.08）。农村地区居民（OR 2.13，95%CI 1.07 - 4.24）和女性（OR 1.53，95%CI 1.06 - 2.22）更易患CIND。
尽管aMCI和CIND患病率较高，但痴呆患病率较低。痴呆与年龄和教育程度密切相关。CIND与居住在农村地区及女性性别有关，而aMCI与文盲有关。
