McDougall D, Bhibhatbhan A, Toth C
Department of Clinical Neurosciences and the University of Calgary, Calgary, AB, Canada.
Acta Neurol Scand. 2009 Nov;120(5):364-7. doi: 10.1111/j.1600-0404.2009.01190.x.
Corticosteroid therapy is known to have long-term adverse effects and complications, but our knowledge of the adverse effects of corticosteroids within a neuromuscular patient population is limited.
We sought to determine the prevalence and impact of corticosteroid use in a population of patients with neuromuscular diseases, as well as possible clinical associations for presence of adverse effects.
A retrospective chart review from a comprehensive database from a tertiary care neuromuscular clinic spanning 1988-2007 was performed.
Corticosteroids led to adverse effects in 74% of exposed patients, without proper prophylaxis considered in about 50% of cases. There were no associations determined to have impact upon adverse effect occurrence, including the exposure to cumulative corticosteroid dosing or diagnosis.
Corticosteroid therapy is frequently associated with adverse effects, although prediction of their occurrence is not clear. Prophylaxis of their occurrence is underperformed in our tertiary care clinic patient population.
已知皮质类固醇疗法具有长期不良反应和并发症，但我们对神经肌肉疾病患者群体中皮质类固醇不良反应的了解有限。
我们试图确定神经肌肉疾病患者群体中使用皮质类固醇的患病率和影响，以及不良反应存在的可能临床关联。
对一家三级护理神经肌肉诊所1988年至2007年综合数据库进行回顾性病历审查。
74%的暴露患者出现皮质类固醇不良反应，约50%的病例未考虑适当预防措施。未确定有对不良反应发生有影响的关联，包括累积皮质类固醇剂量暴露或诊断。
皮质类固醇疗法常伴有不良反应，但其发生的预测尚不清楚。在我们的三级护理诊所患者群体中，对其发生的预防措施执行不足。
