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爱尔兰实施工作场所禁烟令前后一年的低出生体重儿和早产儿发生率。

Low birthweight and preterm birth rates 1 year before and after the Irish workplace smoking ban.

机构信息

Tobacco Free Research Institute (RIFTFS), Dublin, Ireland.

出版信息

BJOG. 2009 Dec;116(13):1782-7. doi: 10.1111/j.1471-0528.2009.02374.x. Epub 2009 Oct 13.

Abstract

OBJECTIVE

It is well-established that maternal smoking has adverse birth outcomes (low birthweight, LBW, and preterm births). The comprehensive Irish workplace smoking ban was successfully introduced in March 2004. We examined LBW and preterm birth rates 1 year before and after the workplace smoking ban in Dublin.

DESIGN

A cross-sectional observational study analysing routinely collected data using the Euroking K2 maternity system.

SETTING

Coombe University Maternal Hospital.

POPULATION

Only singleton live births were included for analyses (7593 and 7648, in 2003 and 2005, respectively).

METHODS

Detailed gestational and clinical characteristics were collected and analysed using multivariable logistic regression analyses and subgroup analyses.

MAIN OUTCOME MEASURES

Maternal smoking rates, mean birthweights, and adjusted odds ratios (ORs) of LBW and preterm births in 2005 versus 2003.

RESULTS

There was a 25% decreased risk of preterm births (OR, 0.75; 95% CI, 0.59-0.96), a 43% increased risk of LBW (OR, 1.43; 95% CI, 1.10-1.85), and a 12% fall in maternal smoking rates (from 23.4 to 20.6%) in 2005 relative to 2003. Such patterns were significantly maintained when specific subgroups were also analysed. Mean birthweights decreased in 2005, but were not significant (P=0.99). There was a marginal increase in smoking cessation before pregnancy in 2005 (P=0.047).

CONCLUSIONS

Significant declines in preterm births and in maternal smoking rates after the smoking ban are welcome signs. However, the increased LBW birth risks might reflect a secular trend, as observed in many industrialised nations, and merits further investigations.

摘要

目的

众所周知,母亲吸烟会对生育结果造成不良影响(低出生体重儿、早产)。2004 年 3 月,爱尔兰全面推行工作场所禁烟令。我们调查了都柏林在工作场所禁烟令实施前后一年的低出生体重儿和早产率。

设计

一项使用 Euroking K2 产妇系统收集常规数据的横断面观察性研究。

地点

库姆大学妇产医院。

人群

仅分析单胎活产(2003 年和 2005 年分别为 7593 例和 7648 例)。

方法

使用多变量逻辑回归分析和亚组分析收集和分析详细的妊娠和临床特征。

主要观察指标

2005 年与 2003 年相比,母亲吸烟率、平均出生体重和调整后的低出生体重儿和早产的比值比(OR)。

结果

早产的风险降低了 25%(OR,0.75;95%CI,0.59-0.96),低出生体重儿的风险增加了 43%(OR,1.43;95%CI,1.10-1.85),母亲吸烟率从 2003 年的 23.4%降至 2005 年的 20.6%(下降 12%)。当对特定亚组进行分析时,这种模式也得到了显著维持。2005 年的平均出生体重下降,但无统计学意义(P=0.99)。2005 年计划怀孕前的戒烟率略有上升(P=0.047)。

结论

禁烟令实施后早产率和母亲吸烟率显著下降是可喜的迹象。然而,增加的低出生体重儿风险可能反映了一种与许多工业化国家类似的长期趋势,值得进一步研究。

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