Silverman Gregg J, Grönwall Caroline, Vas Jaya, Chen Yifang
Medicine, University of California San Diego, La Jolla, California 92024-0663, United States.
Discov Med. 2009 Oct;8(42):151-6.
The evolution of the immune system has provided a multilevel system that interconnects the innate and adaptive immune systems to serve at least three central purposes: the defense from microbial pathogens, the capacity for discrimination of self- from non-self necessary for the prevention of autoimmune disease, and essential effector roles in wound repair and tissue remodeling. In recent studies, we have elucidated an unsuspected role for a class of naturally occurring autoreactive antibodies from the most primitive tier of B lymphocytes, which regulates fundamental functions of the innate immune system. Our findings also throw light onto long unresolved mysteries regarding the origins of the earliest waves of B lymphocyte development.
免疫系统的进化提供了一个多层次的系统，该系统将先天免疫系统和适应性免疫系统相互连接，以实现至少三个核心目的：抵御微生物病原体、区分自我与非自我以预防自身免疫性疾病，以及在伤口修复和组织重塑中发挥重要的效应作用。在最近的研究中，我们阐明了一类来自最原始B淋巴细胞层的天然存在的自身反应性抗体的意想不到的作用，这类抗体调节先天免疫系统的基本功能。我们的发现还揭示了关于B淋巴细胞最早发育浪潮起源的长期未解决的谜团。
