New restriction fragment length polymorphism (probe E9) reveals the highest linkage disequilibrium in Italian CF patients.
作者信息
Devoto M, De Benedetti L, Ronchetto P, Romano L, Romeo G, Tsui L C, Dean M, Collins F, Seia M, Piceni Sereni L
机构信息
Laboratorio de Genetica Molecolare, Istituto G. Gaslini, Genova, Italy.
出版信息
Acta Univ Carol Med (Praha). 1990;36(1-4):102-4.
PMID:1983379
Abstract
We report that the allele distribution for RFLP's flanking the CF gene differs between patients with and without pancreatic insufficiency. The present study confirms this difference. In both classes the linkage disequilibrium (LD) is highest with the RFLP revealed by probe E9. The haplotype distribution identified by these RFLP's can be used for indirect carrier detection.
摘要
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