Varga Viktor, Losonczy Attila, Zemelman Boris V, Borhegyi Zsolt, Nyiri Gábor, Domonkos Andor, Hangya Balázs, Holderith Noémi, Magee Jeffrey C, Freund Tamás F
Institute of Experimental Medicine, Budapest 1083, Hungary.
Science. 2009 Oct 16;326(5951):449-53. doi: 10.1126/science.1178307.
Cortical information processing is under state-dependent control of subcortical neuromodulatory systems. Although this modulatory effect is thought to be mediated mainly by slow nonsynaptic metabotropic receptors, other mechanisms, such as direct synaptic transmission, are possible. Yet, it is currently unknown if any such form of subcortical control exists. Here, we present direct evidence of a strong, spatiotemporally precise excitatory input from an ascending neuromodulatory center. Selective stimulation of serotonergic median raphe neurons produced a rapid activation of hippocampal interneurons. At the network level, this subcortical drive was manifested as a pattern of effective disynaptic GABAergic inhibition that spread throughout the circuit. This form of subcortical network regulation should be incorporated into current concepts of normal and pathological cortical function.
皮质信息处理受皮质下神经调节系统的状态依赖性控制。尽管这种调节作用被认为主要由缓慢的非突触代谢型受体介导，但其他机制，如直接突触传递，也是有可能的。然而，目前尚不清楚是否存在任何这种形式的皮质下控制。在这里，我们提供了来自一个上行神经调节中心的强烈、时空精确的兴奋性输入的直接证据。选择性刺激血清素能中缝正中神经元可使海马中间神经元快速激活。在网络层面，这种皮质下驱动表现为一种有效的双突触GABA能抑制模式，该模式遍布整个回路。这种形式的皮质下网络调节应纳入当前关于正常和病理皮质功能的概念中。
