Department of Neurology, University Hospital of Cologne, 50924 Cologne, Germany.
Seizure. 2009 Dec;18(10):716-8. doi: 10.1016/j.seizure.2009.09.005.
We report on a case of epilepsia partialis continua with rapid response to intravenous bolus administration of levetiracetam. A 60-year-old woman presented with continuous jerking of the right foot and hallux persisting for more than two days. She had a 9-year history of epilepsy due to a left temporoparietal oligodendroglioma with occasional focal seizures clinically presenting as speech arrest, which was treated with levetiracetam and oxcarbazepine administered orally. After hospital admission, the twitching of the foot and toe was refractory to add-on treatment with lorazepam and diazepam but stopped within 15 min after intravenous bolus administration of 2000 mg levetiracetam. This observation suggests that intravenous bolus administration of levetiracetam may be an effective therapeutic option in epilepsia partialis continua.
我们报告了一例部分连续性癫痫发作，静脉推注左乙拉西坦后迅速起效。一名 60 岁女性因左颞顶叶少突胶质细胞瘤导致癫痫，病史 9 年，偶尔出现局灶性癫痫发作，临床表现为言语中断，口服左乙拉西坦和奥卡西平治疗。住院后，足部和脚趾抽搐对加用劳拉西泮和地西泮治疗无反应，但静脉推注 2000 毫克左乙拉西坦后 15 分钟内停止。这一观察结果表明，静脉推注左乙拉西坦可能是部分连续性癫痫发作的有效治疗选择。
