Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 2 Medical Drive, Singapore 117597, Singapore.
Int J Biochem Cell Biol. 2010 Feb;42(2):230-40. doi: 10.1016/j.biocel.2009.10.007. Epub 2009 Oct 29.
Environmental genomics has revolutionised how researchers can study the molecular basis of adverse effects of environmental toxicants. It is expected that the new discipline will afford efficient and high-throughput means to delineate mechanisms of action, risk assessment, identify and understand basic pathogenic mechanisms that are critical to disease progression, predict toxicity of unknown agents and to more precisely phenotype disease subtypes. Previously, we have demonstrated the potential of environmental genomics in a toxicant exposure model and, perhaps, this might become a crucial tool in biological response marker or biomarker discovery. To illustrate how toxicogenomics can be useful, we provide here an overview of some of the past and potential future aspects of environmental genomics. The present article also reviews the principles and technological concerns, and the standards and databases of toxicogenomics. In addition, applications of toxicogenomics in drug target identifications and validation strategies are also discussed.
环境基因组学极大地改变了研究人员研究环境毒物不良影响的分子基础的方式。预计这一新学科将提供高效、高通量的手段来描绘作用机制、风险评估、识别和理解对疾病进展至关重要的基本发病机制、预测未知物质的毒性，并更准确地表现疾病亚型。以前，我们已经在毒物暴露模型中证明了环境基因组学的潜力，也许这将成为生物反应标志物或生物标志物发现的重要工具。为了说明毒理基因组学的有用性，我们在此概述了环境基因组学的一些过去和潜在的未来方面。本文还回顾了毒理基因组学的原理和技术关注点，以及标准和数据库。此外，还讨论了毒理基因组学在药物靶点鉴定和验证策略中的应用。
