Akerström Göran, Stålberg Peter
Department of Surgery, University Hospital, Uppsala, 751 85 Sweden.
Surg Clin North Am. 2009 Oct;89(5):1047-68. doi: 10.1016/j.suc.2009.06.016.
Multiple endocrine neoplasia syndrome type 1 (MEN-1) consists of endocrine tumors of the parathyroid, the endocrine pancreas-duodenum, and the pituitary. Surveillance and screening for the endocrinopathies is recommended in gene carriers. Surgery for MEN-1-related hyperparathyroidism is generally performed as radical subtotal parathyroidectomy, because less surgery is likely to result in persistent or recurrent disease. Multiple endocrine neoplasia syndrome type 2 (MEN-2) consists of medullary thyroid carcinoma, pheochromocytoma, and hyperparathyroidism. Prophylactic thyroidectomy based on DNA testing in the MEN-2 syndrome is considered one of the greater achievements in cancer treatment, because it may be performed before thyroid carcinoma development and provides cure for the patient.
1型多发性内分泌肿瘤综合征（MEN - 1）由甲状旁腺、内分泌胰腺 - 十二指肠和垂体的内分泌肿瘤组成。建议对基因携带者的内分泌疾病进行监测和筛查。MEN - 1相关甲状旁腺功能亢进症的手术通常采用根治性甲状旁腺次全切除术，因为手术范围较小可能会导致疾病持续或复发。2型多发性内分泌肿瘤综合征（MEN - 2）由甲状腺髓样癌、嗜铬细胞瘤和甲状旁腺功能亢进症组成。基于MEN - 2综合征的DNA检测进行预防性甲状腺切除术被认为是癌症治疗的重大成就之一，因为它可以在甲状腺癌发生之前进行，从而为患者提供治愈的可能。
