Sherman Scott K, Howe James R
Department of Surgery, Carver College of Medicine, The University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA.
Surg Oncol Clin N Am. 2013 Oct;22(4):857-84. doi: 10.1016/j.soc.2013.06.012. Epub 2013 Jul 26.
This article reviews translational research in endocrine surgery, with a focus on disorders of the thyroid, parathyroids, adrenals, and endocrine pancreas. Discovery of genes responsible for heritable endocrine cancer syndromes has increased knowledge of the causes and mechanisms of endocrine cancer and has refined surgical treatment options. Knowledge of mutations in sporadic cancer has led to rapid progress in small-molecule kinase inhibitor strategies. These breakthroughs and their influence on current therapy are discussed to provide surgeons with an overview of the basic science research currently creating new clinical treatments and improving patient care.
本文回顾了内分泌外科的转化研究，重点关注甲状腺、甲状旁腺、肾上腺和内分泌胰腺的疾病。对遗传性内分泌癌综合征相关基因的发现，增加了我们对内分泌癌病因和机制的了解，并优化了手术治疗方案。对散发性癌症中突变的认识，推动了小分子激酶抑制剂策略的快速发展。本文将讨论这些突破及其对当前治疗的影响，以便为外科医生提供基础科学研究的概述，这些研究目前正在创造新的临床治疗方法并改善患者护理。
