Modena and Reggio Emilia University, Department of Geriatrics, NOCSAE (Nuovo Ospedale Civile S. Agostino-Estense), Baggiovara (MO), Italy.
Arch Gerontol Geriatr. 2009;49 Suppl 1:5-12. doi: 10.1016/j.archger.2009.09.006.
IGF-1 decline has been related to age-dependent cognitive impairment and dementia. No study examined IGF-1 levels in subjects with a risk factor for brain damage such as hypertension. We investigated the relationship between IGF-1, cognitive functioning and neuroimaging in a sample of 75 hypertensive elderly subjects aged > 65. Cognitive performance were tested by mini mental state examination (MMSE), Cambridge cognitive examination (CAMDEX-R), and the frontal assessment battery (FAB). Among other indices, free IGF-1 in serum was assayed. The radial width of the temporal horn (rWTH) evaluates medial cerebral temporal lobe atrophy. Significant correlations between IGF-1 levels and both total and sub-domain scores of cognition were found. IGF-1 level was significantly lower in cognitively declined group. The lowest IGF-1 -percentile subgroup was significantly cognitively impaired. A statistically non-significant, but lower IGF-1 level was found in the sub-sample with pathologically wider rWTH. Levels of IGF-1 below 79.4 microg/l are associated with cognitive decline, whereas a level above 118 microg/l seems to be a marker of normal cognitive performance. A decreasing of IGF-1 related to a widening of the rWTH suggests an involvement of this hormone in hippocampus atrophy.
IGF-1 的下降与年龄相关的认知障碍和痴呆有关。没有研究检查过有脑损伤风险因素（如高血压）的受试者中的 IGF-1 水平。我们在 75 名年龄>65 岁的高血压老年受试者中研究了 IGF-1、认知功能和神经影像学之间的关系。认知表现通过简易精神状态检查（MMSE）、剑桥认知检查（CAMDEX-R）和额叶评估电池（FAB）进行测试。在其他指标中，检测了血清中的游离 IGF-1。颞角的径向宽度（rWTH）评估内侧大脑颞叶萎缩。IGF-1 水平与认知的总分和子域评分之间存在显著相关性。认知下降组的 IGF-1 水平明显较低。IGF-1 百分位数最低的亚组认知障碍明显。在 rWTH 病理性增宽的亚样本中发现 IGF-1 水平虽然无统计学意义但较低。IGF-1 水平低于 79.4μg/l 与认知下降相关，而水平高于 118μg/l 似乎是正常认知表现的标志物。与 rWTH 增宽相关的 IGF-1 减少表明这种激素参与了海马体萎缩。
