Queensland Brain Institute, University of Queensland, Brisbane, Australia; Metro South Addiction & Mental Health Service, Queensland Health, Australia.
Metro South Addiction & Mental Health Service, Queensland Health, Australia.
Ageing Res Rev. 2018 Mar;42:14-27. doi: 10.1016/j.arr.2017.12.002. Epub 2017 Dec 9.
Insulin-like Growth Factor 1 (IGF-1) and its signaling pathway play a primary role in normal growth and ageing, however serum IGF-1 is known to reduce with advancing age. Recent findings suggest IGF-1 is essential for neurogenesis in the adult brain, and this reduction of IGF-1 with ageing may contribute to age-related cognitive decline. Experimental studies have shown manipulation of the GH/GF-1 axis can slow rates of cognitive decline in animals, making IGF-1 a potential biomarker of cognition, and/or its signaling pathway a possible therapeutic target to prevent or slow age-related cognitive decline. A systematic literature review and qualitative narrative summary of current evidence for IGF-1 as a biomarker of cognitive decline in the ageing brain was undertaken. Results indicate IGF-1 concentrations do not confer additional diagnostic information for those with cognitive decline, and routine clinical measurement of IGF-1 is not currently justified. In cases of established cognitive impairment, it remains unclear whether increasing circulating or brain IGF-1 may reverse or slow down the rate of further decline. Advances in neuroimaging, genetics, neuroscience and the availability of large well characterized biobanks will facilitate research exploring the role of IGF-1 in both normal ageing and age-related cognitive decline.
胰岛素样生长因子 1（IGF-1）及其信号通路在正常生长和衰老中起着主要作用，然而，已知血清 IGF-1 随着年龄的增长而降低。最近的研究结果表明，IGF-1 对成人大脑中的神经发生至关重要，并且随着年龄的增长 IGF-1 的减少可能导致与年龄相关的认知能力下降。实验研究表明，对 GH/GF-1 轴的操纵可以减缓动物的认知能力下降速度，这使得 IGF-1 成为认知的潜在生物标志物，并且/或者其信号通路可能成为预防或减缓与年龄相关的认知能力下降的治疗靶点。对 IGF-1 作为衰老大脑中认知能力下降的生物标志物的当前证据进行了系统的文献回顾和定性叙述性总结。结果表明，IGF-1 浓度对于有认知能力下降的患者并没有提供额外的诊断信息，目前没有理由常规临床测量 IGF-1。在认知障碍已确立的情况下，尚不清楚增加循环或大脑 IGF-1 是否可以逆转或减缓进一步下降的速度。神经影像学、遗传学、神经科学的进步以及大型特征明确的生物库的可用性将促进研究探索 IGF-1 在正常衰老和与年龄相关的认知能力下降中的作用。
