Department of Medicine and Sciences of Aging, University G.d'Annunzio, Chieti, Italy.
Arch Gerontol Geriatr. 2009;49 Suppl 1:221-6. doi: 10.1016/j.archger.2009.09.032.
Fas and Fas ligand (FasL), members of the tumor necrosis factor (TNF) and TNF-receptor (TNFR) families of molecules, are involved in apoptosis. They are expressed in membrane-associated as well as soluble forms (sFas, and sFasL). Apoptotic defects underlie some models of autoimmune diseases, and they have been proposed in the pathogenesis of systemic lupus erythematosus (SLE) a prototypic autoimmune disorder. We measured the serum levels of sFas and sFasL in a series of well characterized SLE patients and devised an index of the two forms which resulted to be associated with age, indicating that apoptosis resistance is modulated during aging, thus explaining the conflicting observations made in previous studies.
Fas 和 Fas 配体（FasL）是肿瘤坏死因子（TNF）和 TNF 受体（TNFR）家族分子的成员，参与细胞凋亡。它们以膜结合和可溶性形式（sFas 和 sFasL）表达。凋亡缺陷是某些自身免疫性疾病的模型基础，并且已经在系统性红斑狼疮（SLE）这一典型的自身免疫性疾病的发病机制中提出。我们在一系列特征明确的 SLE 患者中测量了血清 sFas 和 sFasL 的水平，并设计了一种这两种形式的指数，结果与年龄相关，表明凋亡抵抗在衰老过程中受到调节，从而解释了以前研究中观察到的相互矛盾的结果。
