Zarnescu Daniela C, Zinsmaier Konrad E
Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA.
Cell. 2009 Oct 16;139(2):229-31. doi: 10.1016/j.cell.2009.09.032.
Secreted Wnt morphogens mediate cell-cell communication, but the mechanism of Wnt transfer between cells is unknown. Korkut et al. (2009) report that the transmembrane protein Evi is a versatile carrier that guides Wingless to presynaptic terminals of motor neurons and then escorts it across the synaptic cleft. In postsynaptic muscles, Evi promotes Frizzled-2 trafficking.
分泌型Wnt形态发生素介导细胞间通讯，但细胞间Wnt转移的机制尚不清楚。Korkut等人（2009年）报告称，跨膜蛋白Evi是一种多功能载体，它将无翅蛋白引导至运动神经元的突触前末端，然后护送其穿过突触间隙。在突触后肌肉中，Evi促进卷曲蛋白-2的运输。
