Kajiwara S
Graduate School of Dentistry, The First Department of Conservative Dentistry, Fukuoka Dental College.
Fukuoka Shika Daigaku Gakkai Zasshi. 1990;17(4):358-82.
This study was designed to elucidate whether or not the root canal sealers, newly prepared here, show high affinities and promote the osteo-cicatric healing for the remaining dental pulp and periapical regions. For these purposes, I used two types of sealers, newly devised here and mainly composed of powdered corals mixed with propyreneglycol for the experiment 1 and powdered human dentins mixed with atelocollagen implant for the experiment 2. Guttapercha points with these sealers were applied in the premolar and molar tooth mesial or distal canals of 24 adult cats, whereas in controls guttapercha points with Canals, made commercially, were used instead of these sealers. After treatment, the periapical tissues and accessory root canal regions were histopathologically observed at different intervals throughout 30 to 130 days. The results obtained were as follows: 1. When guttapercha points were penetrated beyond the apical foramen and reached periapical tissues, prolonged inflammatory reactions of a slight or medium degree were observed in all three types of sealers. 2. When Canals were applied, prolonged inflammatory reactions were persistent if the sealer flooded out. In contrast, if they were in just-filling (Type-I, as termed in text), inflammatory reactions were often detectable at the accessory root regions. Many exudative inflammatory cells around the over-tip of guttapercha points were seen, as compared around the apicals of the dental root. 3. When powdered coral was used, strong inflammatory reactions was little found. Adjunction of the new bone was usually observed in the alveolar bone. The tendency of scar formations was seen in the periapical tissues where the inflammatory reaction was assumed to have occurred. 4. When powdered human dentin was used, in any experiments, inflammatory reaction were not seen with a few exceptions. However, if inflammatory responses were existed in a few cases, their degrees were relatively strong. 5. If the debris of dentin was blocked within the root canal apex, fine examples were seen regardless of the three types of the sealers. 6. Calcium in the powdered coral showed a conspicuous peak by energy X-ray analysis. The ratio of Ca and P of powdered human dentin was 1:1. From the above findings, both powdered coral and powdered human dentin could be useful as composites of sealers.
本研究旨在阐明在此新制备的根管封闭剂是否具有高亲和力，并促进剩余牙髓和根尖周区域的骨瘢痕愈合。出于这些目的，在实验1中，我使用了两种在此新设计的、主要由与丙二醇混合的粉末状珊瑚组成的封闭剂，在实验2中使用了与去端胶原蛋白植入物混合的粉末状人牙本质。将带有这些封闭剂的牙胶尖应用于24只成年猫的前磨牙和磨牙的近中或远中根管，而在对照组中，使用市售的牙胶尖代替这些封闭剂。治疗后，在30至130天的不同时间间隔对根尖周组织和副根管区域进行组织病理学观察。获得的结果如下：1. 当牙胶尖超出根尖孔并到达根尖周组织时，在所有三种类型的封闭剂中均观察到轻度或中度的持续性炎症反应。2. 当使用Canals时，如果封闭剂溢出，则持续性炎症反应会持续。相比之下，如果它们处于刚好填充（文中称为I型）状态，则在副根管区域通常可检测到炎症反应。与牙根根尖周围相比，在牙胶尖尖端周围可见许多渗出性炎症细胞。3. 当使用粉末状珊瑚时，很少发现强烈的炎症反应。通常在牙槽骨中观察到新骨的附着。在假定发生炎症反应的根尖周组织中可见瘢痕形成的趋势。4. 当使用粉末状人牙本质时，在任何实验中，除少数例外均未观察到炎症反应。然而，如果在少数情况下存在炎症反应，其程度相对较强。5. 如果牙本质碎屑阻塞在根管根尖内，无论三种类型的封闭剂如何，均可见到良好的例子。6. 通过能量X射线分析，粉末状珊瑚中的钙显示出明显的峰值。粉末状人牙本质的Ca和P之比为1:1。从上述发现来看，粉末状珊瑚和粉末状人牙本质都可作为封闭剂的复合材料。
