Laboratory Animal Center of the Academy of Military Medical Science, No. 20, Dongdajie Street, Fengtai District, Beijing 100071, China.
Vet Microbiol. 2010 Mar 24;141(3-4):374-8. doi: 10.1016/j.vetmic.2009.09.024. Epub 2009 Sep 26.
An outbreak of canine distemper virus (CDV) in hand-feeding Rhesus monkeys in China was reported. Twenty Rhesus monkeys presented blood and mucus in feces, respiratory symptoms, anorexia, acute fever, thicken of footpad and red rashes in the faces over 1-month period. CDV infection was identified by characteristic clinical signs, the specific detection of the BIT Rapid color CDV detection kit, electron microscopy and the results of sequence aligning. A phylogenetic analysis further confirmed that the CDV in the Rhesus monkeys belonged to the clade of the epidemic CDV types of China. All the infected monkeys were monitored and treated with antiserum therapy. The antiserum therapy seemed more effective for adult monkeys than young monkeys. Twelve monkeys died. The high mortality might indicate that the virulence of CDV to monkeys was enhanced. This is the first report we are aware of documenting Rhesus monkeys infected with CDV in China. Urgent work should be done to prevent the possibly epidemic of CDV in non-human primate.
中国报道了一起人工喂养猕猴犬瘟热病毒（CDV）爆发事件。二十只猕猴出现粪便带血和黏液、呼吸道症状、食欲不振、急性发热、脚垫增厚和面部红疹等症状，持续时间超过 1 个月。通过特征性临床症状、BIT 快速颜色 CDV 检测试剂盒的特异性检测、电子显微镜和序列比对结果鉴定出 CDV 感染。系统发育分析进一步证实，猕猴中的 CDV 属于中国流行 CDV 类型的分支。所有感染的猴子都接受了抗血清治疗。抗血清治疗对成年猴子似乎比年轻猴子更有效。十二只猴子死亡。高死亡率可能表明 CDV 对猴子的毒力增强。这是我们首次在中国有记录的猕猴感染 CDV 的报告。应紧急开展工作，防止 CDV 在非人类灵长类动物中可能爆发。
