Lai P K, Alpers M P, MacKay-Scollay E M
Int J Cancer. 1977 Jul 15;20(1):21-9. doi: 10.1002/ijc.2910200106.
When sensitized leukocytes were re-exposed to EBV antigen or to tuberculin-purified protein derivatives, they produced lymphokines, including the migration inhibition factor, which inhibited the migration of guinea-pig peritoneal exudate cells, and other lymphokines with the characteristics of interferon, which inhibited EBV-induced transformation and EBV superinfection of target cells. Unsensitized leucocytes from sero-negative adults and from neonates did not produce lymphokines when challenged with the antigens. This indicates that cell-mediated immunity and its associated soluble mediators may be involved in the control of EBV infection and that the interferon release assay is a useful in vitro correlate for the study of cellular immunity to EBV.
当致敏白细胞再次接触EBV抗原或结核菌素纯化蛋白衍生物时，它们会产生淋巴因子，包括抑制豚鼠腹腔渗出细胞迁移的迁移抑制因子，以及具有干扰素特性的其他淋巴因子，这些淋巴因子可抑制EBV诱导的靶细胞转化和EBV超感染。血清阴性的成年人和新生儿的未致敏白细胞在受到抗原刺激时不会产生淋巴因子。这表明细胞介导的免疫及其相关的可溶性介质可能参与了EBV感染的控制，并且干扰素释放试验是研究针对EBV的细胞免疫的一种有用的体外相关检测方法。
