Takagawa Ryo, Makino Hirochika, Kimura Jun, Hiroshima Yukihiko, Oshima Takashi, Nagano Yasuhiko, Fujii Syoichi, Kunisaki Chikara
Dept. of Surgery, Gastroenterological Center, Yokohama City University.
Gan To Kagaku Ryoho. 2009 Oct;36(10):1749-51.
A 70-year-old male patient had advanced gastric cancer with severe lymph node metastasis. He was treated by combination chemotherapy of S-1 120 mg/body (1-week administration and 1-week rest)and docetaxel (DOC) 40 mg/body( day 1 and 15). After 2 courses of treatment, the primary lesion was remarkably improved and para-aortic lymph nodes disappeared by CT scan, so we diagnosed it as a partial response (PR). Anemia (WHO grade 3) was observed as toxicity and treated with transfusion. This regimen could be performed on an outpatient basis for over 2 years, and the response was maintained on CT and endoscopic examination after 20 courses of treatment. The biweekly docetaxel and S-1 combination chemotherapy was thought to be an effective method as chemotherapy for an outpatient with advanced gastric cancer.
一名70岁男性患者患有晚期胃癌，伴有严重的淋巴结转移。他接受了S-1 120mg/体（给药1周，休息1周）和多西他赛（DOC）40mg/体（第1天和第15天）的联合化疗。经过2个疗程的治疗，主要病灶明显改善，CT扫描显示腹主动脉旁淋巴结消失，因此我们将其诊断为部分缓解（PR）。观察到贫血（WHO 3级）为毒性反应，并进行了输血治疗。该方案可在门诊进行2年以上，20个疗程治疗后，CT和内镜检查均维持了缓解状态。每两周一次的多西他赛和S-1联合化疗被认为是晚期胃癌门诊患者化疗的有效方法。
