Yamamoto Takayuki, Shikano Toshio, Hattori Keisuke, Kinoshita Takashi, Hachisuka Takehiro, Mori Toshihiro, Shinohara Masahiko, Miyauchi Masayuki
Dept. of Transplant Surgery, Nagoya Dai Ni Red Cross Hospital.
Gan To Kagaku Ryoho. 2010 Aug;37(8):1569-71.
We report a case of a 77-year-old man with gastric cancer of Borrmann type 3, pyloric stenosis and liver invasion. Distal gastrectomy with liver film resection was performed. Pathological staging was IV(sig, pT4, pN2, H0, P0, CY0, M0, ly3, v3). We recommended adjuvant chemotherapy but the patient refused. He was diagnosed with a recurrence of peritoneal dissemination 4 months after the operation. He received docetaxel(DOC)at a starting dose of 40 mg/m2 by iv infusion on day 1 and S- 1 at a full dose of 100 mg/body daily for two weeks every three weeks. After 5 cycles of this combination therapy, the gastric cancer with peritoneal dissemination completely disappeared. He was recognized to have grade 2 hematologic toxicity, hand foot syndrome and stomatitis, and all treatment-related toxicities were resolved. No re-growth of gastric cancer has been seen for 9 months with this chemotherapy.
我们报告一例77岁男性，患有Borrmann 3型胃癌、幽门狭窄并伴有肝转移。行远端胃切除术并肝包膜切除术。病理分期为IV期（sig，pT4，pN2，H0，P0，CY0，M0，ly3，v3）。我们建议进行辅助化疗，但患者拒绝。术后4个月，他被诊断为腹膜播散复发。他接受多西他赛（DOC），第1天静脉输注起始剂量为40mg/m²，S-1每天全剂量100mg/体，每三周服用两周。经过5个周期的这种联合治疗后，伴有腹膜播散的胃癌完全消失。他出现了2级血液学毒性、手足综合征和口腔炎，所有与治疗相关的毒性均已缓解。接受这种化疗后9个月未见胃癌复发。
