Tamura Jun, Nakayama Yuusuke, Kitaguchi Kazuhiko, Ura Katsuaki, Taira Kaoru, Ooe Hideaki, Yoshikawa Akira, Ishigami Shun-Ichi, Baba Nobuo
Dept. of Surgery, Otsu Red Cross Hospital.
Gan To Kagaku Ryoho. 2009 Oct;36(10):1769-72.
A 75-year-old woman underwent resection of gastrointestinal stromal tumor (GIST) of small intestine in 1999. In January 2006, she suffered liver dysfunction and abdominal CT revealed she had a large liver metastasis. At first the tumor in the right lobe progressed to the medial segment and seemed unresectable. She twice underwent transarterial embolization and treatment with 400mg/day of imatinib mesylate. Then percutaneous transhepatic portal embolization was performed. As a result, liver metastasis markedly decreased in size, and extended right lobectomy of the liver was performed in June 2006. A large portion of the liver metastasis showed necrosis, but histopathological examination revealed focal remnants of viable tumor cells. In March 2007, radiofrequency ablation was performed for recurrence of remnant liver. The patient has been treated by imatinib mesylate and is alive with no evidence of tumor recurrence.
一名75岁女性于1999年接受了小肠胃肠道间质瘤（GIST）切除术。2006年1月，她出现肝功能障碍，腹部CT显示有巨大肝转移瘤。起初，右叶肿瘤进展至内侧段，似乎无法切除。她接受了两次经动脉栓塞术，并接受了每天400毫克甲磺酸伊马替尼的治疗。随后进行了经皮经肝门静脉栓塞术。结果，肝转移瘤明显缩小，2006年6月进行了扩大右肝叶切除术。大部分肝转移瘤出现坏死，但组织病理学检查发现有存活肿瘤细胞的局灶性残留。2007年3月，对残留肝脏的复发灶进行了射频消融。该患者一直接受甲磺酸伊马替尼治疗，目前存活，无肿瘤复发迹象。
