Department of Toxicology, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
Toxicol Mech Methods. 2009 Nov;19(9):547-51. doi: 10.3109/15376510903350371.
The influence of the combination of oximes on the reactivating and therapeutic efficacy of antidotal treatment of acute soman poisoning was evaluated. The ability of two combinations of oximes (HI-6 + trimedoxime and HI-6 + K203) to reactivate soman-inhibited acetylcholinesterase and reduce acute toxicity of soman was compared with the reactivating and therapeutic efficacy of antidotal treatment involving single oxime (HI-6, trimedoxime, K203) using in vivo model. Studies determining percent of reactivation of soman-inhibited blood and diaphragm acetylcholinesterase in poisoned rats showed that the reactivating efficacy of both combinations of oximes is slightly greater than the reactivating efficacy of the most effective individual oxime, but the difference among them is not significant. Both combinations of oximes were found to be as effective in the reduction of acute lethal toxic effects in soman-poisoned mice as the antidotal treatment involving the most efficacious individual oxime. Thus, the efficacy of oximes is comparative in rats vs mice. A comparison of reactivating and therapeutic efficacy of individual oximes showed that the newly developed oxime K203 is approximately as effective as commonly used trimedoxime; nevertheless, their reactivating and therapeutic efficacy is markedly lower compared to the oxime HI-6. Based on the obtained data, one can conclude that the antidotal treatment involving chosen combinations of oximes does not significantly influence the potency of the most effective individual oxime (HI-6) to reactivate soman-inhibited rat acetylcholinesterase and to reduce acute toxicity of soman.
研究了肟类化合物组合对急性梭曼中毒解毒治疗的再激活和治疗效果的影响。通过体内模型比较了两种肟类化合物组合（HI-6+trimedoxime 和 HI-6+K203）与单肟类化合物（HI-6、trimedoxime、K203）解毒治疗再激活梭曼抑制的乙酰胆碱酯酶和降低梭曼急性毒性的能力。研究表明，两种肟类化合物组合再激活中毒大鼠血液和膈肌乙酰胆碱酯酶的效果略高于最有效单肟类化合物的再激活效果，但它们之间的差异不显著。两种肟类化合物组合在降低梭曼中毒小鼠的急性致死毒性方面与最有效单肟类化合物的解毒治疗同样有效。因此，肟类化合物在大鼠和小鼠中的疗效相当。个体肟类化合物的再激活和治疗效果的比较表明，新开发的肟类化合物 K203 与常用的 trimedoxime 效果相当；然而，与 HI-6 相比，它们的再激活和治疗效果明显较低。基于获得的数据，可以得出结论，所选肟类化合物组合的解毒治疗不会显著影响最有效单肟类化合物（HI-6）再激活梭曼抑制的大鼠乙酰胆碱酯酶和降低梭曼急性毒性的效力。
