Boulanger Lisa M
Department of Molecular Biology, 123 Lewis Thomas Laboratories, Princeton University, Washington Road, Princeton, NJ 08544, USA.
Neuron. 2009 Oct 15;64(1):93-109. doi: 10.1016/j.neuron.2009.09.001.
Many proteins first identified in the immune system are also expressed in the developing and adult nervous system. Unexpectedly, recent studies reveal that a number of these proteins, in addition to their immunological roles, are essential for the establishment, function, and modification of synaptic connections. These include proinflammatory cytokines (e.g., TNFalpha, IL-6), proteins of the innate immune system (e.g., complement C1q and C3, pentraxins, Dscam), members of the major histocompatibility complex class I (MHCI) family, and MHCI-binding immunoreceptors and their components (e.g., PIRB, Ly49, DAP12, CD3zeta). Understanding how these proteins function in neurons will clarify the molecular basis of fundamental events in brain development and plasticity and may add a new dimension to our understanding of neural-immune interactions in health and disease.
许多最初在免疫系统中被鉴定出的蛋白质也在发育中的和成年的神经系统中表达。出乎意料的是，最近的研究表明，这些蛋白质中的许多，除了其免疫作用外，对于突触连接的建立、功能和修饰也是必不可少的。这些蛋白质包括促炎细胞因子（如肿瘤坏死因子α、白细胞介素-6）、先天免疫系统的蛋白质（如补体C1q和C3、五聚素、唐氏综合征细胞黏附分子）、主要组织相容性复合体I类（MHCI）家族的成员，以及与MHCI结合的免疫受体及其成分（如PIRB、Ly49、DAP12、CD3ζ）。了解这些蛋白质在神经元中的功能将阐明大脑发育和可塑性基本事件的分子基础，并可能为我们理解健康和疾病中的神经免疫相互作用增添新的维度。
