Amelimojarad Mandana, Amelimojarad Melika, Cui Xiaonan
Department of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Front Aging Neurosci. 2024 Jul 3;16:1391517. doi: 10.3389/fnagi.2024.1391517. eCollection 2024.
As the most common cause of dementia, Alzheimer's disease (AD) is characterized by neurodegeneration and synaptic loss with an increasing prevalence in the elderly. Increased inflammatory responses triggers brain cells to produce pro-inflammatory cytokines and accelerates the Aβ accumulation, tau protein hyper-phosphorylation leading to neurodegeneration. Therefore, in this paper, we discuss the current understanding of how inflammation affects brain activity to induce AD pathology, the inflammatory biomarkers and possible therapies that combat inflammation for AD.
作为痴呆症最常见的病因，阿尔茨海默病（AD）的特征是神经退行性变和突触丧失，且在老年人中的患病率不断上升。炎症反应增强会触发脑细胞产生促炎细胞因子，并加速β淀粉样蛋白（Aβ）的积累、tau蛋白的过度磷酸化，从而导致神经退行性变。因此，在本文中，我们讨论了目前对于炎症如何影响大脑活动以诱发AD病理、炎症生物标志物以及对抗AD炎症的可能疗法的理解。
