Lim Hoong Sern, Beadle Roger, Frenneaux Michael
Am J Cardiol. 2009 Nov 1;104(9):1311-4. doi: 10.1016/j.amjcard.2009.06.050.
The overall mortality rate in patients with heart failure with normal ejection fraction (HFNEF) appears to be comparable to that in patients with heart failure with reduced ejection fraction. In contrast to the latter group of patients, randomized trials with neurohumoral blockade in patients with HFNEF have failed to demonstrate reduction in mortality. This is at least in part related to the lower proportion of heart failure-related death in the overall population of patients with HFNEF. In conclusion, better characterization of patients with HFNEF at greatest risk for heart failure-related death and understanding the risks of the different modes of death would allow more effective use of specific heart failure medical or device therapy in patients with HFNEF.
射血分数正常的心力衰竭（HFNEF）患者的总体死亡率似乎与射血分数降低的心力衰竭患者相当。与后一组患者不同，针对HFNEF患者进行的神经体液阻滞剂随机试验未能证明死亡率降低。这至少部分与HFNEF患者总体人群中心力衰竭相关死亡比例较低有关。总之，更好地识别HFNEF患者中与心力衰竭相关死亡风险最高的患者，并了解不同死亡模式的风险，将有助于更有效地对HFNEF患者使用特定的心力衰竭药物或器械治疗。
