子痫前期与后续发生糖尿病的风险
Preeclampsia and risk of developing subsequent diabetes.
作者信息
Carr D B, Newton K M, Utzschneider K M, Tong J, Gerchman F, Kahn S E, Easterling T R, Heckbert S R
机构信息
Department of Obstetrics & Gynecology, University of Washington, Seattle, WA 98195-6460, USA.
出版信息
Hypertens Pregnancy. 2009 Aug;28(4):435-47. doi: 10.3109/10641950802629675.
OBJECTIVE
Determine whether preeclampsia is associated with developing diabetes.
METHODS
Subsequent diabetes was ascertained using ICD-9 codes, pharmacy and glucose data in a retrospective cohort study of 2,032 women with preeclampsia and 29,431 without preeclampsia.
RESULTS
During a median follow-up of 8.2 years, 342 women developed diabetes. Preeclampsia was associated with a higher risk of diabetes adjusting for age, primigravidity, and gestational diabetes (hazard ratio, HR 1.82, 95%CI 1.26, 2.62) and in women without gestational diabetes (n = 30,109; HR 1.86, 95%CI 1.22, 2.84).
CONCLUSION
Women with preeclampsia have greater risk of developing diabetes, even in the absence of gestational diabetes.
目的
确定子痫前期是否与患糖尿病有关。
方法
在一项对2032例患子痫前期的女性和29431例未患子痫前期的女性进行的回顾性队列研究中，使用国际疾病分类第九版（ICD - 9）编码、药房记录和血糖数据来确定后续发生的糖尿病情况。
结果
在中位随访8.2年期间，有342名女性患糖尿病。在校正年龄、初孕情况和妊娠期糖尿病后，子痫前期与患糖尿病的风险较高相关（风险比，HR 1.82，95%置信区间1.26，2.62），在无妊娠期糖尿病的女性中（n = 30109；HR 1.86，95%置信区间1.22，2.84）也是如此。
结论
子痫前期女性患糖尿病的风险更高，即使在没有妊娠期糖尿病的情况下也是如此。
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