Paraskeva Anteia, Chatziara Vassiliki, Siafaka Ioanna, Zotou Marianna, Fassoulaki Argyro
Department of Anesthesiology, Aretaieio Hospital,Medical School, University of Athens, Athens, Greece.
Anesth Analg. 2009 Nov;109(5):1684-7. doi: 10.1213/ANE.0b013e3181b7c4f6.
We investigated a possible effect of ondansetron on the duration of sensory and motor block produced by ropivacaine.
Fifty male patients undergoing transurethral surgery received either 8 mg oral ondansetron the evening before surgery plus IV 8 mg ondansetron 15 min before subarachnoid anesthesia or placebo. All patients received 2.2 mL of 0.75% plain ropivacaine intrathecally. Sensory and motor block were assessed 30 min after the intrathecal injection and every 30 min thereafter until recovery from the motor block.
Thirty minutes after spinal injection of ropivacaine, we first measured, in both groups, the time to maximum block for both sensory and motor modalities. The maximum level of the sensory block, defined as decreased sensation, was T8 in the control and T6 in the ondansetron group, and absence of sensation was defined as T11 and T9 for the control and the ondansetron groups, respectively. Regarding block duration, 180 min after spinal injection, sensory block was detected in 11 of 22 and 16 of 24 patients and motor block in 1 of 22 and 0 of 24 in the control and ondansetron groups, respectively. Sensory and motor block did not differ between groups at any measured time point.
Ondansetron had no effect on the subarachnoid sensory or motor block produced by ropivacaine.
我们研究了昂丹司琼对罗哌卡因产生的感觉和运动阻滞持续时间的可能影响。
50例接受经尿道手术的男性患者，在手术前一晚口服8mg昂丹司琼，加上在蛛网膜下腔麻醉前15分钟静脉注射8mg昂丹司琼或安慰剂。所有患者鞘内注射2.2mL 0.75%的罗哌卡因原液。在鞘内注射后30分钟评估感觉和运动阻滞情况，此后每30分钟评估一次，直至运动阻滞恢复。
在鞘内注射罗哌卡因30分钟后，我们首次测量了两组患者感觉和运动模式达到最大阻滞的时间。感觉阻滞的最大平面，以感觉减退定义，对照组为T8，昂丹司琼组为T6；感觉消失分别定义为对照组T11，昂丹司琼组T9。关于阻滞持续时间，在鞘内注射180分钟后，对照组22例中有11例、昂丹司琼组24例中有16例仍存在感觉阻滞，对照组22例中有1例、昂丹司琼组24例中无1例存在运动阻滞。在任何测量时间点，两组之间的感觉和运动阻滞均无差异。
昂丹司琼对罗哌卡因产生的蛛网膜下腔感觉或运动阻滞无影响。
