Department of Anesthesiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
Kaohsiung J Med Sci. 2010 Apr;26(4):167-74. doi: 10.1016/S1607-551X(10)70025-5.
The aim of This study was to compare spinal, low-dose spinal, and epidural anesthesia using ropivacaine and fentanyl combinations for transurethral surgical procedures. Sixty patients with American Society of Anesthesiologists scores of I-III were allocated into three groups. After pre- loading with 5 mL/kg normal saline, patients in the spinal anesthesia group (Group S) received 15 mg of hyperbaric ropivacaine plus 25 microg of fentanyl intrathecally; patients in the epidural anesthesia group (Group E) received 112.5 mg of ropivacaine plus 25 microg of fentanyl epidurally via an epidural catheter; and patients in the low-dose spinal anesthesia group (Group L) received 10 mg of hyperbaric ropivacaine plus 25 microg of fentanyl intrathecally. Blood pressure, heart rate, peripheral oxygen saturation, time to onset of thoracic (T)-10 dermatome, two-segment sensorial block regression time, full recovery of sensorial block, maximum motor blockade levels, motor blockade regression time, additional analgesic administration, patient comfort, and complications were recorded. The time to the onset of T10 dermatome level was shortest in Group S and longest in Group E (p < 0.001). The sensorial blockade time and motor blockade regression time were shorted in Group L (p < 0.001). The two-segment sensorial block regression time in Group E exceeded that in the other groups. Additional analgesic administration was not needed in any group. No complications or adverse effects were observed in any patient. We conclude that all three anesthetic techniques may be used safely and are appropriate for transurethral surgical procedures. However, low-dose spinal anesthesia with ropivacaine plus fentanyl may be preferable in transurethral surgery because we reach an adequate sensorial level with less motor blockade.
本研究旨在比较罗哌卡因和芬太尼联合用于经尿道手术的脊髓、低剂量脊髓和硬膜外麻醉。将 60 名美国麻醉医师协会评分 I-III 的患者分为三组。在预负荷 5 mL/kg 生理盐水后,脊髓麻醉组(S 组)患者接受 15 mg 重比重罗哌卡因加 25 μg 芬太尼鞘内注射;硬膜外麻醉组(E 组)患者通过硬膜外导管给予 112.5 mg 罗哌卡因加 25 μg 芬太尼硬膜外麻醉;低剂量脊髓麻醉组(L 组)患者接受 10 mg 重比重罗哌卡因加 25 μg 芬太尼鞘内注射。记录血压、心率、外周血氧饱和度、胸 (T)-10 皮节起效时间、两阶段感觉阻滞消退时间、感觉阻滞完全恢复时间、最大运动阻滞水平、运动阻滞消退时间、额外镇痛药物的使用、患者舒适度和并发症。T10 皮节水平起效时间最短的是 S 组,最长的是 E 组(p < 0.001)。L 组感觉阻滞时间和运动阻滞消退时间较短(p < 0.001)。E 组两阶段感觉阻滞消退时间超过其他组。任何组均无需额外镇痛药物。没有观察到任何患者出现并发症或不良反应。我们得出结论,三种麻醉技术均可安全使用,适用于经尿道手术。然而,低剂量罗哌卡因加芬太尼脊髓麻醉在经尿道手术中可能更可取,因为我们达到了足够的感觉水平,运动阻滞较少。