Haedo Mariana R, Gerez Juan, Fuertes Mariana, Giacomini Damiana, Páez-Pereda Marcelo, Labeur Marta, Renner Ulrich, Stalla Gunter K, Arzt Eduardo
Laboratorio de Fisiología y Biología Molecular, Departamento de Fisiología y Biología Molecular y Celular, FCEN, Universidad de Buenos Aires, Buenos Aires, Argentina.
Horm Res. 2009;72(5):266-74. doi: 10.1159/000245928. Epub 2009 Oct 19.
Research performed on the pituitary has proven that cytokines play an important role in maintaining pituitary physiology, affecting not only cell proliferation but also hormone secretion. The effects of cytokines can be autocrine or paracrine. This review gives an overview on the effects of the most studied cytokines in the pituitary. Special interest is focused on interleukin-6 (IL-6) because it has the distinctive characteristic of stimulating pituitary tumor cell growth, but has the opposite effect on normal pituitary cells. On the other hand, IL-6 is a cytokine of interest in the pituitary because recent work has shown that it promotes and maintains senescence in certain types of tumors. Given that the majority of pituitary adenomas are microadenomas and the fact that clinically inapparent pituitary tumors are quite common, senescence, perhaps mediated by IL-6, is an attractive mechanism for explaining the benign nature of pituitary tumors.
对垂体进行的研究已证明，细胞因子在维持垂体生理功能方面发挥着重要作用，不仅影响细胞增殖，还影响激素分泌。细胞因子的作用可以是自分泌或旁分泌。本综述概述了垂体中研究最多的细胞因子的作用。特别关注白细胞介素-6（IL-6），因为它具有刺激垂体肿瘤细胞生长的独特特性，但对正常垂体细胞却有相反的作用。另一方面，IL-6是垂体中一个受关注的细胞因子，因为最近的研究表明它在某些类型的肿瘤中促进并维持细胞衰老。鉴于大多数垂体腺瘤是微腺瘤，且临床上不明显的垂体肿瘤相当常见，由IL-6介导的细胞衰老可能是解释垂体肿瘤良性本质的一个有吸引力的机制。
