Sato Mitsuo, Suzuki Masaaki, Suzuki Jun-ichi, Endo Yuri, Chiba Yoshiaki, Matsuura Masato, Nakagawa Kenzo, Mataki Shiro, Kurosaki Norimasa, Hasegawa Makoto
Department of Sleep-Related Respiratory Disorders, Tokyo Medical and Dental University Graduate School, Japan.
J Med Dent Sci. 2008 Mar;55(1):43-7.
We investigated differences in the depth of hypoxia produced by apneic events of the same duration (30 seconds) amongst patients with different degrees of OSAS according to their AIs (apnea indices). The relationship between apnea duration (seconds) and fall in oxygen saturation (%) was evaluated by means of a linear regression analysis. The fall induced by a 30-second apnea event was designated as the "oxygen desaturation value 30" (ODV30). We analyzed the polysomnographic recordings of 122 OSAS patients who showed significant correlations (p<0.01) between apnea duration and subsequent fall in oxygen saturation and calculated their respective ODV30. We evaluated the influence of AI and BMI on ODV30 by multi-comparison and found out that standardized partial regression coefficients of BMI and AI were 0.578 and 0.148, respectively (multi-regression analysis, SPSS). BMI was proved to be more influential on ODV30 than AI was. On the other hand, the ODV30 of mild, moderate and severe OSAS patients was 8.84 +/- 2.62% (Mean +/- S.D.), 8.25 +/- 2.45% and 10.59 +/- 3.32%, respectively. Our study shows that fall in oxygen saturation is particularly extensive in severe OSAS patients and that fall in oxygen saturation is deepened as obesity increases. We think ODV30 is a useful variable for evaluating OSAS.
我们根据呼吸暂停指数（AI），对不同程度阻塞性睡眠呼吸暂停低通气综合征（OSAS）患者中持续时间相同（30秒）的呼吸暂停事件所产生的低氧深度差异进行了研究。通过线性回归分析评估呼吸暂停持续时间（秒）与血氧饱和度下降（%）之间的关系。将30秒呼吸暂停事件引起的血氧饱和度下降定义为“30秒氧饱和度下降值”（ODV30）。我们分析了122例OSAS患者的多导睡眠图记录，这些患者的呼吸暂停持续时间与随后的血氧饱和度下降之间存在显著相关性（p<0.01），并计算了各自的ODV30。我们通过多重比较评估了AI和体重指数（BMI）对ODV30的影响，发现BMI和AI的标准化偏回归系数分别为0.578和0.148（多元回归分析，SPSS）。结果证明，BMI对ODV30的影响比AI更大。另一方面，轻度、中度和重度OSAS患者的ODV30分别为8.84±2.62%（平均值±标准差）、8.25±2.45%和10.59±3.32%。我们的研究表明，重度OSAS患者的血氧饱和度下降尤为显著，且随着肥胖程度增加，血氧饱和度下降程度加深。我们认为ODV30是评估OSAS的一个有用变量。
