Center for Biomedical Engineering, and Department of Chemical and Nuclear Engineering, University of New Mexico, Albuquerque, New Mexico 87131, USA.
Langmuir. 2010 Jan 19;26(2):1380-5. doi: 10.1021/la902470b.
The sustained liquid flow of a typical lateral flow assay can be mimicked by two-dimensional shaped, thin porous membranes, specifically rectangular membranes appended to circular sectors. In designing these fan-shaped devices, we have been aided by analytical equations and finite-element simulations. We show both mathematically and experimentally how a continuous increase in unwetted pore volume causes a deviation from traditional imbibition, and leads to quasi-stationary flow in the rectangular element. These results are both theoretically and practically important because they indicate how medical diagnostic test strips may be fabricated without incorporating an absorbent pad.
典型的侧向流动分析物的持续液体流动可以通过二维形状的薄多孔膜来模拟，特别是附接到圆形扇区的矩形膜。在设计这些扇形装置时，我们得到了分析方程和有限元模拟的帮助。我们从理论和实验两个方面展示了未润湿的孔体积连续增加如何导致与传统吸吮的偏离，并导致矩形元件中的准稳定流动。这些结果在理论和实践上都很重要，因为它们表明可以在不包含吸收垫的情况下制造医疗诊断测试条。
