Infectious Diseases Branch, Division of Communicable Disease Control, Center for Infectious Diseases, California Department of Public Health, Richmond, CA, USA.
Epidemiol Infect. 2010 Apr;138(4):507-11. doi: 10.1017/S0950268809990999. Epub 2009 Oct 22.
Coccidioidomycosis results from inhaling spores of the fungus Coccidioides spp. in soil or airborne dust in endemic areas. We investigated an outbreak of coccidioidomycosis in a 12-person civilian construction crew that excavated soil during an underground pipe installation on Camp Roberts Military Base, California in October 2007. Ten (83.3%) workers developed symptoms of coccidioidomycosis; eight (66.7%) had serologically confirmed disease, seven had abnormal chest radiographs, and one developed disseminated infection; none used respiratory protection. A diagnosis of coccidioidomycosis in an eleventh worker followed his exposure to the outbreak site in 2008. Although episodic clusters of infections have occurred at Camp Roberts, the general area is not associated with the high disease rates found in California's San Joaquin Valley. Measures to minimize exposure to airborne spores during soil-disrupting activities should be taken before work begins in any coccidioides-endemic area, including regions with only historic evidence of disease activity.
球孢子菌病是由吸入土壤或流行地区空气中的真菌球孢子菌属孢子引起的。我们调查了 2007 年 10 月在加利福尼亚州罗伯茨营军事基地进行地下管道安装时挖掘土壤的 12 名平民建筑工人中的球孢子菌病爆发事件。10 名（83.3%）工人出现球孢子菌病症状；8 名（66.7%）血清学确诊，7 名胸部 X 线异常，1 名发生播散性感染；无人使用呼吸道防护。2008 年，第 11 名工人在接触疫情爆发地后被诊断患有球孢子菌病。尽管在罗伯茨营间歇性发生了感染集群，但该地区与加利福尼亚州圣华金河谷发现的高疾病发生率无关。在任何球孢子菌流行地区（包括仅具有疾病活动历史证据的地区）开始工作之前，应采取措施减少在破坏土壤活动中吸入空气传播孢子的风险。
