Mayer C, Kalogjera V, Lievre C, Pautler J, Weisel M L, Mayer S
Sem Hop. 1977;53(25-28):1511-6.
In this study, we tried to make a comparison between the findings concerning two human strong anti Factor VIII inhibitors. In one case, the strong inhibitor appeared in an old man without any particular antecedant. In the second case, it occurred in a young hemophiliac A. We found in both cases that the inhibitor was a immunoglobulin G with light chain lambda. Its activity site is on the fragment AB. These anticoagulants have a inhibitory action against only the Factor VIII procoagulant fraction and have exclusively neutralising properties. The inhibitor present in the non hemophiliac patient has particularly great resistance to temperature and pH variations.
在本研究中，我们试图对关于两种人类强效抗凝血因子VIII抑制剂的研究结果进行比较。在一个病例中，强效抑制剂出现在一位无任何特殊既往史的老年男性身上。在第二个病例中，它出现在一名年轻的甲型血友病患者身上。我们在这两个病例中均发现，该抑制剂是一种带有λ轻链的免疫球蛋白G。其活性位点位于AB片段上。这些抗凝剂仅对凝血因子VIII促凝部分具有抑制作用，且仅具有中和特性。非血友病患者体内的抑制剂对温度和pH变化具有特别强的耐受性。
