血清（1-3）-β-D-葡聚糖作为人类免疫缺陷病毒感染或血液恶性肿瘤患者肺孢子菌肺炎诊断的工具。
Serum (1-3)-beta-D-glucan as a tool for diagnosis of Pneumocystis jirovecii pneumonia in patients with human immunodeficiency virus infection or hematological malignancy.
机构信息
Department of Medical Diagnostic Sciences, Dienst Laboratoriumgeneeskunde, University Hospitals Leuven, 3000 Leuven, Belgium.
出版信息
J Clin Microbiol. 2009 Dec;47(12):3871-4. doi: 10.1128/JCM.01756-09. Epub 2009 Oct 21.
Abstract
(1-3)-Beta-D-Glucan (BG) reactivity was tested in serum samples from 28 patients with human immunodeficiency virus infection or a hematological malignancy and Pneumocystis jirovecii pneumonia (PCP) and 28 control patients. The sensitivity and specificity of BG detection with the Fungitell assay for PCP were 100 and 96.4%, respectively, using a cutoff value of 100 pg/ml. Serum BG testing looks promising for the noninvasive diagnosis of PCP. Our data suggest that a higher cutoff value for the diagnosis of PCP than for the diagnosis of invasive aspergillosis or candidiasis could be used safely and will improve the specificity of the test.
摘要
（1-3）-β-D-葡聚糖（BG）反应性在 28 例人类免疫缺陷病毒感染或血液系统恶性肿瘤合并肺孢子菌肺炎（PCP）患者和 28 例对照患者的血清样本中进行了检测。使用 100pg/ml 的截断值，Fungitell 检测 BG 对 PCP 的敏感性和特异性分别为 100%和 96.4%。血清 BG 检测似乎是一种很有前途的非侵入性诊断 PCP 的方法。我们的数据表明，用于诊断 PCP 的截断值高于用于诊断侵袭性曲霉病或念珠菌病的截断值，这样做是安全的，并且可以提高该检测的特异性。
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